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| Cai,Xin-jun; Wang,Zeng; Xu,Ying-ying; Ye,Lihong; Cao,Jia-wei; Ni,Jian-jun; Wu,Ting-ting. |
| The Ruanjian Sanjie Decoction (RSD) is a traditional Chinese medicine (TCM) formulation consisting of Spica Prunellae, Pseudobulbus Cremastrae Seu Pleiones, Concha Ostreae and Semen Coicis, and widely used as an adjuvant in anti-cancer therapy. The aim of this study was to determine the effects of RSD on the extracellular matrix (ECM) of tumors, and on the efficacy of anti-cancer nano-formulations in a tumor-bearing mouse model. The mice were treated with triptolide encapsulated in PEG-modified liposomes (TP-PEG-LPs), either alone or in combination with RSD. The combination treatment significantly retarded tumor growth relative to the untreated controls, indicating the potent adjuvant effect of RSD in targeted anti-cancer therapy. In addition, RSD also... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Traditional Chinese medicine; Ruanjian Sanjie Decoction; Tumor matrix; Anti-tumor efficacy; Nano-formulations. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100605 |
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