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| Costa,Ramon Teixeira; Araújo,Orlei Ribeiro de; Brunialti,Milena Karina Coló; Assunção,Murilo Santucci Cesar; Azevedo,Luciano César Pontes; Freitas,Flávio; Salomão,Reinaldo. |
| ABSTRACT Objective: We evaluated the kinetics of cytokines belonging to the T helper1 (Th1), Th2, and Th17 profiles in septic patients, and their correlations with organ dysfunction and hospital mortality. Methods: This was a prospective observational study in a cohort of septic patients admitted to the intensive care units (ICU) of three Brazilian general hospitals. A total of 104 septic patients and 53 health volunteers (controls) were included. Plasma samples were collected within the first 48 h of organ dysfunction or septic shock (0D), after seven (D7) and 14 days (D14) of follow-up. The following cytokines were measured by flow cytometry: Interleukin-1β (IL-1β), IL-2, IL-6, IL-8, IL-10, IL-12/23p40, IL-17, IL-21, tumor necrosis factor-α (TNF-α),... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sepsis; Cytokines; Th response; Organ dysfunction; SOFA. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200079 |
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| Salomão,R.; Ferreira,B.L.; Salomão,M.C.; Santos,S.S.; Azevedo,L.C.P.; Brunialti,M.K.C.. |
| Sepsis remains a major cause of morbidity and mortality worldwide, with increased burden in low- and middle-resource settings. The role of the inflammatory response in the pathogenesis of the syndrome has supported the modern concept of sepsis. Nevertheless, a definition of sepsis and the criteria for its recognition is a continuous process, which reflects the growing knowledge of its mechanisms and the success and failure of diagnostic and therapeutic interventions. Here we review the evolving concepts of sepsis, from the “systemic inflammatory response syndrome triggered by infection” (Sepsis-1) to “a severe, potentially fatal, organic dysfunction caused by an inadequate or dysregulated host response to infection” (Sepsis-3). We focused in the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Sepsis-3; Inflammatory response; Immunometabolism; QSOFA; SOFA. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000400301 |
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