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| AJAMI,MARJAN; EGHTESADI,SHAHRIAR; PAZOKI-TOROUDI,HAMIDREZA; HABIBEY,ROUHOLLAH; EBRAHIMI,SOLTAN AHMED. |
| Crocus sativus, known as saffron, is used in folk medicine for treatment of different types of diseases, and its anti-inflammatory and free radical scavenging activities have been demonstrated. The present study evaluated gentamicin nephrotoxicity in saffron treated rats. Male Wistar rats (200-250g) were treated with saffron (40 or 80 mg/k/d) for 10 days, or saffron (40 or 80 mg/ kg/d) for 10 days and gentamicin 80 mg/kg/d for five days, starting from day 6. At the end of treatment, blood samples were taken for measurement of serum creatinine (SCr) and BUN. The left kidney was prepared for histological evaluation and the right kidney for Malondialdehyde (MDA) measurement. Gentamicin 80 (mg/k/d) increased SCr, BUN and renal tissue levels of MDA and induced... |
| Tipo: Journal article |
Palavras-chave: Saffron; Malondialdehyde (MDA); Aminoglycoside; Renal failure. |
| Ano: 2010 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000100010 |
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