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| Oliveira,Isadora S; Ferreira,Isabela G; Alexandre-Silva,Gabriel M; Cerni,Felipe A; Cremonez,Caroline M; Arantes,Eliane C; Zottich,Umberto; Pucca,Manuela B. |
| Abstract Scorpion venoms are natural sources of molecules that have, in addition to their toxic function, potential therapeutic applications. In this source the neurotoxins can be found especially those that act on potassium channels. Potassium channels are responsible for maintaining the membrane potential in the excitable cells, especially the voltage-dependent potassium channels (Kv), including Kv1.3 channels. These channels (Kv1.3) are expressed by various types of tissues and cells, being part of several physiological processes. However, the major studies of Kv1.3 are performed on T cells due its importance on autoimmune diseases. Scorpion toxins capable of acting on potassium channels (KTx), mainly on Kv1.3 channels, have gained a prominent role for... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Voltage-gated potassium channels; Kv1.3; Scorpion toxins; KTx; Immunosuppression. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100202 |
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| Nencioni,Ana Leonor Abrahão; Beraldo Neto,Emidio; Freitas,Lucas Alves de; Dorce,Valquiria Abrão Coronado. |
| Abstract In Brazil, the scorpion species responsible for most severe incidents belong to the Tityus genus and, among this group, T. serrulatus, T. bahiensis, T. stigmurus and T. obscurus are the most dangerous ones. Other species such as T. metuendus, T. silvestres, T. brazilae, T. confluens, T. costatus, T. fasciolatus and T. neglectus are also found in the country, but the incidence and severity of accidents caused by them are lower. The main effects caused by scorpion venoms - such as myocardial damage, cardiac arrhythmias, pulmonary edema and shock - are mainly due to the release of mediators from the autonomic nervous system. On the other hand, some evidence show the participation of the central nervous system and inflammatory response in the process.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Brazilian scorpions; Central nervous system; Scorpion venom; Scorpion toxins. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100202 |
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