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| Oukkache,Naoual; Chgoury,Fatima; Lalaoui,Mekki; Cano,Alejandro Alagón; Ghalim,Noreddine. |
| Background The present study compared two methods used successfully in a large-scale program for the collection of scorpion venoms, namely the milking of adult scorpions via manual and electrical stimulation. Results Our immunobiochemical characterizations clearly demonstrate that regularly applied electrical stimulation obtains scorpion venom more easily and, most importantly, in greater quantity. Qualitatively, the electrically collected venom showed lack of hemolymph contaminants such as hemocyanin. In contrast, manual obtainment of venom subjects scorpions to maximal trauma, leading to hemocyanin secretion. Our study highlighted the importance of reducing scorpion trauma during venom milking. Conclusions In conclusion, to produce high quality antivenom... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Scorpion venoms; Manual stimulation; Electrical stimulation; Antivenom; Lethality. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100303 |
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| Contreras-Ortiz,José María Eloy; Vázquez-Chagoyán,Juan Carlos; Martínez-Castañeda,José Simón; Estrada-Franco,José Guillermo; Aparicio-Burgos,José Esteban; Acosta-Dibarrat,Jorge; Barbabosa-Pliego,Alberto. |
| Background : The venom of Centruroides limpidus limpidus (Cll) is a mixture of pharmacologically active principles. The most important of these are toxic proteins that interact both selectively and specifically with different cellular targets such as ion channels. Recently, anticancer properties of the venom from other scorpion species have been described. Studies in vitro have shown that scorpion venom induces cell death, inhibits proliferation and triggers the apoptotic pathway in different cancer cell lines. Herein, after treating human cervical adenocarcinoma (HeLa) cells with Cll crude venom, their cytotoxic activity and apoptosis induction were assessed. Results : Cll crude venom induced cell death in normal macrophages in a dose-dependent manner.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Scorpion venoms; Cytotoxic tests; Apoptosis; HeLa cells; Anticancer agents; Centruroides toxins. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100311 |
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| Fatani,A. J.; Al-Zuhair,H. A.; Yaquob,H. I.; Abdel-Fattah,A. A.; El-Sayed,M. I.; El-Sayed,F. A.. |
| Oxidative stress and proteases have been implicated in several diseases and extensive evidence indicates that antioxidants and protease inhibitors help prevent organ functional damage. Leiurus quinquestriatus (LQQ) scorpion venom causes cellular injuries that may lead to multiple organ failure. Thus, the capability of the antioxidant "natural standardized extract of Gingko biloba leaves (Gin, EGb 761)" and the non-selective protease inhibitor, aprotinin, in ameliorating venom-induced biochemical alterations indicative of cellular injury and oxidative stress was studied to determine their effectiveness in protecting rats from venom-evoked cellular damages. Thus, in this study, rats were treated with LQQ venom (0.3mg.kg-1, subcutaneously) alone or after Gin... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leiurusquinquestriatus; Ginkgo; Aprotinin; Scorpion venoms. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000200008 |
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