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Inadequate timing between corticosteroid and antibiotics applications increases mortality due to sepsis 55
Fadel,Marcus Vinícius Telles; Repka,João Carlos; Cunha,Cláudio Leinig Pereira da; Leão,Maria Terezinha C..
This study tested the hypothesis that the use of corticosteroids prior to antibiotics can lower the mortality rate in severe infections by S. aureus or Gram-negative bacilli, using an animal model. This study was a prospective and controlled study, placed in a university laboratory. Seven hundred and sixty mice distributed into three groups (Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae infected). The interventions in each group were: I) infection control (intra-peritoneal); II) treatment solely with antibiotics (teicoplanin or amikacin); III) antibiotics administered prior to the corticosteroid (methylprednisolone); IV) antibiotics administered after the corticosteroid. Mortality in the E. coli group, subgroup I: 100%; subgroup II: 55%...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Adrenal cortex hormones; Antibiotics; Sepsis; Survival; Mice; Animals; Laboratory; Severe infection; Peritonitis; Shock; Endotoxin.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500013
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Marteiliosis in mussels: a rare disease? 5
Gombac, Mitja; Kusar, D.; Ocepek, M.; Pogacnik, Milan; Arzul, Isabelle; Couraleau, Yann; Jenclc, V..
Among 1280 cultured and wild adult Mediterranean mussels, Mytilus galloprovincialis, collected over a 1-year surveillance period from the Slovene Adriatic Sea, 0.3% were histologically positive for the presence of Marteilia spp. The infection was concentrated in winter. Employing the molecular methods of PCR, cloning, DNA restriction and sequencing, only Marteilia refringens type M was detected in all the infected mussels. Although all life-cycle stages of M. refringens severely infected digestive glands, only sporadic disruption of epithelial cells of digestive tubules and focal destruction of digestive tubules were observed in the infected mussels. This was the first detection of M. refringens in M. galloprovincialis from the Slovene Adriatic Sea with...
Tipo: Text Palavras-chave: Prevalence; Marteilia refringens type M.; Mediterranean mussels Mytilus galloprovincialis; Sequencing; Severe infection; Slovene Adriatic Sea.
Ano: 2014 URL: http://archimer.ifremer.fr/doc/00165/27640/26064.pdf
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