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	Provedor de dados BJMBR (13) Biol. Res. (5) Anais da ABC (AABC) (3) Genet. Mol. Biol. (3) Biocell (1) Braz. J. Plant Physiol. (1) Electron. J. Biotechnol. (1) Mais... Autor ORTEGA,XIMENA (2) ALMARZA,CAROLINA (1) Armelin,H.A. (1) BUBIS,JOSÉ (1) Barja-Fidalgo,C. (1) Beckmann,Svenja (1) Brochado,S.M. (1) CARVAJAL,CRISTIAN (1) CASTAÑEDA,PATRICIA (1) Cabral,A.L.B. (1) Castro,R.M.R.P.S. (1) Chaves,Ana Lúcia Soares (1) Chen,Cuixia (1) Clemente,C.F.M.Z. (1) Coelho,A.L.J. (1) Craig,Alister G. (1) Cruz,Laura N. (1) Cui,Lingling (1) Cukierman,E. (1) Eichler,C.B. (1) Mais... Palavra-chave Signal transduction (27) Trypanosoma cruzi (3) Cell invasion (2) Citrus limon (2) Integrin (2) Malaria (2) Oxidative stress (2) ACTH (1) Activation (1) Acute myeloid leukemia (1) Adenylyl cyclase (1) Antioxidant enzymatic defenses (1) Antioxidants (1) Atherosclerosis (1) Bradykinin (1) CGMP-dependent protein kinases (cGKs) (1) COS-7 cells (1) Ca2+ homeostasis (1) Ca2+ mobilization (1) Calcium response (1) Mais... Tipo do documento Info:eu-repo/semantics/article (20) Journal article (6) Info:eu-repo/semantics/other (1) Ano 2012 (1) 2011 (3) 2010 (2) 2009 (1) 2008 (1) 2006 (3) 2005 (1) 2004 (1) 2003 (3) 2002 (4) 2001 (2) 2000 (3) 1999 (2) Mais... País Brazil (20) Chile (6) Argentina (1) Idioma Inglês (27)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 27 Primeira ... 1 2 ... Última Signal transduction in Plasmodium-Red Blood Cells interactions and in cytoadherence Anais da ABC (AABC) Cruz,Laura N.; Wu,Yang; Craig,Alister G.; Garcia,Célia R.S.. Malaria is responsible for more than 1.5 million deaths each year, especially among children (Snow et al. 2005). Despite of the severity of malaria situation and great effort to the development of new drug targets (Yuan et al. 2011) there is still a relative low investment toward antimalarial drugs. Briefly there are targets classes of antimalarial drugs currently being tested including: kinases, proteases, ion channel of GPCR, nuclear receptor, among others (Gamo et al. 2010). Here we review malaria signal transduction pathways in Red Blood Cells (RBC) as well as infected RBCs and endothelial cells interactions, namely cytoadherence. The last process is thought to play an important role in the pathogenesis of severe malaria. The molecules displayed on the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cytoadherence; Erythrocyte; Malaria; Plasmodium; Signal transduction. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000200024 Characterization of the cGMP-dependent protein kinase SmcGK1 of Schistosoma mansoni Anais da ABC (AABC) Leutner,Silke; Beckmann,Svenja; Grevelding,Christoph G. Schistosomes are trematode parasites and of worldwide medical importance for humans and animals. Growth and development of these parasites require a specific host environment, but also permanent communication processes between the two genders. Accumulating molecular evidence indicates that the responsible interactions are mediated by signal transduction processes. Conserved signaling molecules were identified, and first approaches made for their characterization. However, no representative of the conserved family of cGMP-dependent protein kinases (cGKs) has been described in this parasite yet. Within the Schistosoma mansoni genome data-set we identified cGK homologs, of which one was investigated in more detail in this study. We present the cloning of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Schistosoma mansoni; Signal transduction; CGMP-dependent protein kinases (cGKs); Serine/threonine (S/T) kinases; Gonad development. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000200023 Molecular basis of mammalian cell invasion by Trypanosoma cruzi Anais da ABC (AABC) Yoshida,Nobuko. Establishment of infection by Trypanosoma cruzi, the agent of Chagas' disease, depends on a series of events involving interactions of diverse parasite molecules with host components. Here we focus on the mechanisms of target cell invasion by metacyclic trypomastigotes (MT) and mammalian tissue culture trypomastigotes (TCT). During MT or TCT internalization, signal transduction pathways are activated both in the parasite and the target cell, leading to Ca2+ mobilization. For cell adhesion, MT engage surface glycoproteins, such as gp82 and gp35/50, which are Ca2+ signal-inducing molecules. In T. cruzi isolates that enter host cells in gp82-mediated manner, parasite protein tyrosine kinase as well as phospholipase C are activated, and Ca2+ is released from I... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Trypomastigotes; Cell invasion; Signal transduction; Ca2+ mobilization. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652006000100010 NFAT regulates CSF-1 gene transcription triggered by L-selectin crosslinking Biocell Chen,Cuixia; Cui,Lingling; Shang,Xin; Zeng,Xianlu. L-selectin is a member of the selectin family that play an important role both in mediating the initial capture and subsequent rolling of leukocytes along the endothelial cells. Furthermore, L-selectin can function as a signal molecule. In our previous studies, we reported that L-selectin ligation could regulate CSF-1 (colony-stimulating factor-1) gene transcription, in which AP-1 acts as a crucial transcriptional factor. Here we investigated the function of the NFAT in the CSF-1 gene transcriptional events. We found that overexpression of WT NFAT induce CSF-1 gene transcription greatly in the activated Jurkat cells. Furthermore, we found that NFAT can be recruited to the nucleus after L-selectin ligation, and the nuclear NFAT interacts with the CSF-1... Tipo: Info:eu-repo/semantics/article Palavras-chave: Signal transduction; Gene transcription; Nuclear transcriptional factor. Ano: 2010 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452010000200001 Divalent cation hinder the solubilization of a tubulin kinase activity from Trypanosoma cruzi epimastigotes Biol. Res. UZCANGA,GRACIELA; GALÁN-CARIDAD,JOSÉ MANUEL; SUAREZ,KAREM NORIS; BUBIS,JOSÉ. Trypanosoma cruzi epimastigotes were extracted under various conditions in order to examine the role of divalent cations in the solubilization of microtubule proteins. When epimastigotes were homogenized in the presence of 5 mM Mg+2 and 5 mM Ca+2, a protein kinase responsible for phosphorylating tubulin, as well as the tubulin that became phosphorylated, remained tightly associated with the parasite particulate and detergent-resistant fractions. On the contrary, tubulin kinase and its substrate were predominantly released into the parasite cytosolic and detergent-soluble fractions, when epimastigotes were extracted in the presence of 5 mM EDTA and 5 mM EGTA. These evidences demonstrated a divalent cation-dependent solubilization of the enzyme responsible... Tipo: Journal article Palavras-chave: Microtubules; Post-translational modification of tubulin; Protein kinase CK2; Protein phosphorylation-dephosphorylation; Signal transduction; Trypanosoma cruzi; Tubulin. Ano: 2003 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000300008 Endothelial cell oxidative stress and signal transduction Biol. Res. FONCEA,ROCIO; CARVAJAL,CRISTIAN; ALMARZA,CAROLINA; LEIGHTON,FEDERICO. Endothelial dysfunction (ED) is an early event in atherosclerotic disease, preceding clinical manifestations and complications. Increased reactive oxygen species (ROS) have been implicated as important mechanisms that contribute to ED, and ROS’s may function as intracellular messengers that modulate signaling pathways. Several intracellular signal events stimulated by ROS have been defined, including the identification of two members of the mitogen activated protein kinase family (ERK1/2 and big MAP kinase, BMK1), tyrosine kinases (Src and Syk) and different isoenzymes of PKC as redox-sensitive kinases. ROS regulation of signal transduction components include the modification in the activity of transcriptional factors such as NFkB and others that result in... Tipo: Journal article Palavras-chave: Oxidative stress; Signal transduction; Gene expression; Endothelial cell; Atherosclerosis; Antioxidants. Ano: 2000 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200008 New insights to the functional role of the T cell-Antigen Presenting Cell immunological synapse Biol. Res. FAROUDI,MUSTAPHA; ZARU,ROSSANA; FAVIER,BENOIT; VALITUTTI,SALVATORE. Three innovative and complementary morphological approaches were employed to study the T cell/antigen presenting cell (APC) interaction: (i) high resolution three-dimensional confocal microscopy of the T cell-APC contact site; (ii) time lapse video recording in living T cells of [Ca2+]I and changes in distribution of various GFP fusion proteins with TCR/CD3-zetacomplex associated- and other signaling components; (iii) measurement of lateral TCR mobility and that of recruited signaling components using techniques based on fluorescence recovery after photo-bleaching. These approaches were combined with biochemical and functional experiments to investigate two principal issues: (A) Recruitment and the three-dimensional arrangement of receptors and signaling... Tipo: Journal article Palavras-chave: T cell antigen receptor; Immunological synapse; T cell antigen receptor; Signal transduction. Ano: 2002 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000200004 Signal transduction in lemon seedlings in the hypersensitive response against Alternaria alternata: participation of calmodulin, G-protein and protein kinases Biol. Res. ORTEGA,XIMENA; POLANCO,RUBÉN; CASTAÑEDA,PATRICIA; PEREZ,LUZ M. The development of an effective hypersensitive response (HR) in any plant system relies, not only in their gene composition and expression, but also on an effective and rapid signal transduction system. Lemon seedlings induce the phenylpropanoid pathway, which results in the de novo biosynthesis of the phytoalexin scoparone, as part of the hypersensitive response against Alternaria alternata. In order to elucidate some of the signaling elements that participate in the development of HR in lemon seedlings, we used several compounds that are known as activators or inhibitors of signal transduction elements in plants or in animal cells. Lemon seedlings treated either with cholera toxin or with phorbol 12-myristate 13-acetate (PMA), in the absence of A.... Tipo: Journal article Palavras-chave: Citrus limon; Hypersensitive response; Signal transduction. Ano: 2002 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000300012 Participation of the phosphoinositide metabolism in the hypersensitive response of Citrus limon against Alternaria alternata Biol. Res. ORTEGA,XIMENA; PÉREZ,LUZ M.. Lemon seedlings inoculated with Alternaria alternata develop a hypersensitive response (HR) that includes the induction of Phenylalanine ammonia-lyase (PAL, E. C. 4.3.1.5) and the synthesis of scoparone. The signal transduction pathway involved in the development of this response is unknown. We used several inhibitors of the Phosphoinositide (PI) animal system to study a possible role of Inositol-1,4,5-triphosphate (IP3 ) in the transduction of the fungal conidia signal in Citrus limon. The HR was only partially inhibited by EGTA, suggesting that not only external but internal calcium as well are necessary for a complete development of the HR. In this plant system, Alternaria alternata induced an early accumulation of the second messenger IP3. When lemon... Tipo: Journal article Palavras-chave: Citrus limon; IP3; Phosphoinositides; Rutaceae; Signal transduction. Ano: 2001 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000100014 Pim-1 kinase inhibits the activation of reporter gene expression in Elk-1 and c-Fos reporting systems but not the endogenous gene expression: an artifact of the reporter gene assay by transient co-transfection BJMBR Yan,B.; Wang,H.; Kon,T.; Li,C.-Y.. We have studied the molecular mechanism and signal transduction of pim-1, an oncogene encoding a serine-threonine kinase. This is a true oncogene which prolongs survival and inhibits apoptosis of hematopoietic cells. In order to determine whether the effects of Pim-1 occur by regulation of the mitogen-activated protein kinase pathway, we used a transcriptional reporter assay by transient co-transfection as a screening method. In this study, we found that Pim-1 inhibited the Elk-1 and NFkappaB transcriptional activities induced by activation of the mitogen-activated protein kinase cascade in reporter gene assays. However, Western blots showed that the induction of Elk-1-regulated expression of endogenous c-Fos was not affected by Pim-1. The phosphorylation... Tipo: Info:eu-repo/semantics/article Palavras-chave: Pim-1 kinase; Signal transduction; Mitogen-activated protein kinase pathway; Elk-1; Reporter assay. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200002 Insights into the physiological function of cellular prion protein BJMBR Martins,V.R.; Mercadante,A.F.; Cabral,A.L.B.; Freitas,A.R.O.; Castro,R.M.R.P.S.. Prions have been extensively studied since they represent a new class of infectious agents in which a protein, PrPsc (prion scrapie), appears to be the sole component of the infectious particle. They are responsible for transmissible spongiform encephalopathies, which affect both humans and animals. The mechanism of disease propagation is well understood and involves the interaction of PrPsc with its cellular isoform (PrPc) and subsequently abnormal structural conversion of the latter. PrPc is a glycoprotein anchored on the cell surface by a glycosylphosphatidylinositol moiety and expressed in most cell types but mainly in neurons. Prion diseases have been associated with the accumulation of the abnormally folded protein and its neurotoxic effects;... Tipo: Info:eu-repo/semantics/article Palavras-chave: PrPc; Cellular function; Transmissible spongiform encephalopathies; Laminin; Signal transduction; Copper. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000500005 Inhibition of cytohesin-1 by siRNA leads to reduced IGFR signaling in prostate cancer BJMBR Weizhong,Zhang; Shuohui,Gao; Hanjiao,Qin; Yuhong,Man; Xiaohua,Yang; Jian,Cao; Lisen,Li. To explore how cytohesin-1 (CYTH-1) small interfering RNA (siRNA) influences the insulin-like growth factor receptor (IGFR)-associated signal transduction in prostate cancer, we transfected human prostate cancer PC-3 cell lines with liposome-encapsulatedCYTH-1 siRNA in serum-free medium and exposed the cells to 100 nM IGF-1. The mRNA and protein levels of the signal molecules involved in the IGFR signaling pathways were determined by real-time PCR and detected by Western blotting. The relative mRNA levels of CYTH-1, c-Myc, cyclinD1 and IGF-1R (CYTH-1 siRNA group vs scrambled siRNA group) were 0.26 vs 0.97, 0.34 vs 1.06, 0.10 vs 0.95, and 0.27 vs 0.41 (P < 0.05 for all), respectively. The relative protein levels of CYTH-1, pIGF-1R, pIRS1, pAkt1, pErk1,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cytohesins; Insulin-like growth factor 1 receptor; Prostate cancer; Signal transduction; SiRNA interference. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000700005 Signal transduction induced in Trypanosoma cruzi metacyclic trypomastigotes during the invasion of mammalian cells BJMBR Yoshida,N.; Favoreto Jr.,S.; Ferreira,A.T.; Manque,P.M.. Penetration of Trypanosoma cruzi into mammalian cells depends on the activation of the parasite's protein tyrosine kinase and on the increase in cytosolic Ca2+ concentration. We used metacyclic trypomastigotes, the T. cruzi developmental forms that initiate infection in mammalian hosts, to investigate the association of these two events and to identify the various components of the parasite signal transduction pathway involved in host cell invasion. We have found that i) both the protein tyrosine kinase activation, as measured by phosphorylation of a 175-kDa protein (p175), and Ca2+ mobilization were induced in the metacyclic forms by the HeLa cell extract but not by the extract of T. cruzi-resistant K562 cells; ii) treatment of parasites with the tyrosine... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Signal transduction; Metacyclic trypomastigotes; Protein kinase; Calcium response; Cell invasion. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000300003 Interruption of the blood-stage cycle of the malaria parasite, Plasmodium chabaudi, by protein tyrosine kinase inhibitors BJMBR Gazarini,M.L.; Garcia,C.R.S.. Malaria is a devastating disease caused by a unicellular protozoan, Plasmodium, which affects 3.7 million people every year. Resistance of the parasite to classical treatments such as chloroquine requires the development of new drugs. To gain insight into the mechanisms that control Plasmodium cell cycle, we have examined the effects of kinase inhibitors on the blood-stage cycle of the rodent malaria parasite, Plasmodium chabaudi. In vitro incubation of red blood cells for 17 h at 37ºC with the inhibitors led to a decrease in the percent of infected cells, compared to control treatment, as follows: genistein (200 µM - 75%), staurosporine (1 µM - 58%), R03 (1 µM - 75%), and tyrphostins B44 (100 µM - 66%) and B46 (100 µM - 68%). All these treatments were... Tipo: Info:eu-repo/semantics/other Palavras-chave: Malaria; Plasmodium chabaudi; Kinase inhibitors; Signal transduction; Genistein; Staurosporin. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001100003 Targeting and translocation of endothelial nitric oxide synthase BJMBR Michel,T.. This review explores advances in our understanding of the intracellular regulation of the endothelial isoform of nitric oxide synthase (eNOS) in the context of its dynamically regulated subcellular targeting. Nitric oxide (NO) is a labile molecule, and may play important biological roles both within the cell in which it is synthesized and in its interactions with nearby cells and molecules. The localization of eNOS within the cell importantly influences the biological role and chemical fate of the NO produced by the enzyme. eNOS, a Ca2+/calmodulin-dependent enzyme, is subject to a complex pattern of intracellular regulation, including co- and post-translational modifications and interactions with other proteins and ligands. In endothelial cells and cardiac... Tipo: Info:eu-repo/semantics/article Palavras-chave: Caveolin; Signal transduction; Nitric oxide synthase; Calmodulin; Estrogen; Bradykinin. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100006 Reactive oxygen species and angiotensin II signaling in vascular cells: implications in cardiovascular disease BJMBR Touyz,R.M.. Diseases such as hypertension, atherosclerosis, hyperlipidemia, and diabetes are associated with vascular functional and structural changes including endothelial dysfunction, altered contractility and vascular remodeling. Cellular events underlying these processes involve changes in vascular smooth muscle cell (VSMC) growth, apoptosis/anoikis, cell migration, inflammation, and fibrosis. Many factors influence cellular changes, of which angiotensin II (Ang II) appears to be amongst the most important. The physiological and pathophysiological actions of Ang II are mediated primarily via the Ang II type 1 receptor. Growing evidence indicates that Ang II induces its pleiotropic vascular effects through NADPH-driven generation of reactive oxygen species (ROS).... Tipo: Info:eu-repo/semantics/article Palavras-chave: Vascular smooth muscle cells; Remodeling; Inflammation; Signal transduction; Reactive oxygen species. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000800018 Adenylyl cyclase types I and VI but not II and V are selectively inhibited by nitric oxide BJMBR Goldstein,J.; Silberstein,C.; Ibarra,C.. Adenylyl cyclase (AC) isoforms catalyze the synthesis of 3',5'-cyclic AMP from ATP. These isoforms are critically involved in the regulation of gene transcription, metabolism, and ion channel activity among others. Nitric oxide (NO) is a gaseous product whose synthesis from L-arginine is catalyzed by the enzyme NO synthase. It has been well established that NO activates the enzyme guanylyl cyclase, but little has been reported on the effects of NO on other important second messengers, such as AC. In the present study, the effects of sodium nitroprusside (SNP), a nitric oxide-releasing compound, on COS-7 cells transfected with plasmids containing AC types I, II, V and VI were evaluated. Total inhibition (~98.5%) of cAMP production was observed in COS-7... Tipo: Info:eu-repo/semantics/article Palavras-chave: Adenylyl cyclase; Nitric oxide; Sodium nitroprusside; Cyclic AMP; COS-7 cells; Signal transduction. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000200002 Proliferative signaling initiated in ACTH receptors BJMBR Lotfi,C.F.P.; Lepique,A.P.; Forti,F.L.; Schwindt,T.T.; Eichler,C.B.; Santos,M.O.; Rebustini,I.T.; Hajj,G.N.M.; Juliano,L.; Armelin,H.A.. This article reviews recent results of studies aiming to elucidate modes of integrating signals initiated in ACTH receptors and FGF2 receptors, within the network system of signal transduction found in Y1 adrenocortical cells. These modes of signal integration should be central to the mechanisms underlying the regulation of the G0->G1->S transition in the adrenal cell cycle. FGF2 elicits a strong mitogenic response in G0/G1-arrested Y1 adrenocortical cells, that includes a) rapid and transient activation of extracellular signal-regulated kinases-mitogen-activated protein kinases (ERK-MAPK) (2 to 10 min), b) transcription activation of c-fos, c-jun and c-myc genes (10 to 30 min), c) induction of c-Fos and c-Myc proteins by 1 h and cyclin D1 protein by... Tipo: Info:eu-repo/semantics/article Palavras-chave: ACTH; FGF2; Signal transduction; MAP kinases; Early response genes. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001000002 Focal adhesion kinase signaling in cardiac hypertrophy and failure BJMBR Franchini,K.G.; Clemente,C.F.M.Z.; Marin,T.M.. Focal adhesion kinase (FAK) is a broadly expressed tyrosine kinase implicated in cellular functions such as migration, growth and survival. Emerging data support a role for FAK in cardiac development, reactive hypertrophy and failure. Data reviewed here indicate that FAK plays a critical role at the cellular level in the responses of cardiomyocytes and cardiac fibroblasts to biomechanical stress and to hypertrophic agonists such as angiotensin II and endothelin. The signaling mechanisms regulated by FAK are discussed to provide insight into its role in the pathophysiology of cardiac hypertrophy and failure. Tipo: Info:eu-repo/semantics/article Palavras-chave: Focal adhesion kinase; Mechanical signaling; Cardiovascular system; Signal transduction. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100008 Mechanisms of cell transformation induced by polyomavirus BJMBR Oliveira,M.L.S.; Brochado,S.M.; Sogayar,M.C.. Polyomavirus is a DNA tumor virus that induces a variety of tumors in mice. Its genome encodes three proteins, namely large T (LT), middle T (MT), and small T (ST) antigens, that have been implicated in cell transformation and tumorigenesis. LT is associated with cell immortalization, whereas MT plays an essential role in cell transformation by binding to and activating several cytoplasmic proteins that participate in growth factor-induced mitogenic signal transduction to the nucleus. The use of different MT mutants has led to the identification of MT-binding proteins as well as analysis of their importance during cell transformation. Studying the molecular mechanisms of cell transformation by MT has contributed to a better understanding of cell cycle... Tipo: Info:eu-repo/semantics/article Palavras-chave: Signal transduction; Malignant transformation; Polyomavirus T antigens; Polyomavirus-induced transcriptional control. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700010 Registros recuperados: 27 Primeira ... 1 2 ... Última

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