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An insight on the role of photosensitizer nanocarriers for Photodynamic Therapy Anais da ABC (AABC)
MESQUITA,MARIANA Q.; DIAS,CRISTINA J.; GAMELAS,SARA; FARDILHA,MARGARIDA; NEVES,MARIA G.P.M.S.; FAUSTINO,MARIA AMPARO F..
ABSTRACT Photodynamic therapy (PDT) is a modality of cancer treatment in which tumor cells are destroyed by reactive oxygen species (ROS) produced by photosensitizers following its activation with visible or near infrared light. The PDT success is dependent on different factors namely on the efficiency of the photosensitizer deliver and targeting ability. In this review a special attention will be given to the role of some drug delivery systems to improve the efficiency of tetrapyrrolic photosensitizers to this type of treatment.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Photodynamic therapy; Drug delivery; Liposomes; Silica nanoparticles; Gold nanoparticles; Polymeric micelles.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301101
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Application of SIO2 nanoparticles AS pretreatment alleviates the impact of drought on the physiological performance of Prunus Mahaleb (Rosaceae) Boletín de la Sociedad
ASHKAVAND,PEYMAN; ZARAFSHAR,MEHRDAD; TABARI,MASOUD; MIRZAIE,JAVAD; NIKPOUR,AMIRREZA; BORDBAR,SEYED KAZEM; STRUVE,DANIEL; STRIKER,GUSTAVO GABRIEL.
We studied the physiological responses of Prunus mahaleb (Mahaleb) seedlings to drought stress when previously irrigated (or not) with different concentrations of SiO2 nanoparticles (SNPs). SNPs were applied at four concentrations (0, 10, 50 and 100 mg L-1) for 45 days, and then seedlings were subjected to three watering treatments including low (300 mL water every 3 d), moderate (150 mL water every 3 d) and severe drought stress (no irrigation) for 19 days. Results showed that gas exchange – photosynthesis, stomatal conductance, and transpiration rate – were significantly less impacted by severe drought stress when seedlings were pretreated with SNPs at high concentrations. Beneficial effects of SNPs pretreatment were evident in the nutritional status of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pre-treatment; Silica nanoparticles; Drought; Stress alleviation; Photosynthesis..
Ano: 2018 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-23722018000200007
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Low density lipoprotein modified silica nanoparticles loaded with docetaxel and thalidomide for effective chemotherapy of liver cancer BJMBR
Ao,Man; Xiao,Xu; Ao,Yazhou.
In the present study, we successfully developed a docetaxel (DTX) and thalidomide (TDD) co-delivery system based on low density lipoprotein (LDL) modified silica nanoparticles (LDL/SLN/DTX/TDD). By employing the tumor homing property of LDL and the drug-loading capability of silica nanoparticles, the prepared LDL/SLN/DTX/TDD was expected to locate and specifically deliver the loaded drugs (DTX and TDD) to achieve effective chemotherapy of liver cancer. In vitro analysis revealed that nano-sized LDL/SLN/DTX/TDD with decent drug loading capabilities was able to increase the delivery efficiency by targeting the low density lipoprotein receptors, which were overexpressed on HepG2 human hepatocellular liver carcinoma cell line, which exerted better cytotoxicity...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Docetaxel; Thalidomide; Low density lipoprotein; Silica nanoparticles; Liver cancer.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000300613
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