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	Provedor de dados Genet. Mol. Biol. (2) Autor Dianovsky,Ján (1) Güven,Gülgün S. (1) Güven,Mehmet (1) Hacihanefioglu,Seniha (1) Holecková,Beáta (1) Onaran,Ilhan (1) Siviková,Katarína (1) Ulutin,Turgut (1) Mais... Palavra-chave Sister chromatid exchanges (2) Benzo[alpha]pyrene (1) Chromosomal aberrations (1) DNA fragmentation (1) Glutathione S-transferase M1 (1) Tolylfluanid-based fungicide (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2011 (1) 2006 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Induction of SCEs and DNA fragmentation in bovine peripheral lymphocytes by in vitro exposure to tolylfluanid-based fungicide Genet. Mol. Biol. Siviková,Katarína; Dianovsky,Ján; Holecková,Beáta. The potential for genotoxic and cytotoxic effects of tolylfluanid-based fungicide (50% active agent) was evaluated using sister chromatid exchange (SCE) and proliferation indices (PI) in cultured bovine peripheral lymphocytes. For the detection of possible genetic damage, DNA fragmentation assay was also applied. Bovine lymphocytes cultured for 72 h were treated with the fungicide at the final concentrations of 1.75, 3.5, 8.75, and 17.5 µg/mL for the last 24 and 48 h of culture without S9 metabolic activation, and during the last 2 h of culture with S9 metabolic activation. In the SCE assays no evidence for genotoxic activity of the fungicide was found in treatments of 24 h without and 2 h with S9. After the 24 h exposure to tolylfluanid, a weak decrease... Tipo: Info:eu-repo/semantics/article Palavras-chave: Tolylfluanid-based fungicide; Sister chromatid exchanges; DNA fragmentation. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100019 Individual sensitivity to cytogenetic effects of benzo[alpha]pyrene in cultured human lymphocytes: influence of glutathione S-transferase M1 genotype Genet. Mol. Biol. Güven,Gülgün S.; Güven,Mehmet; Onaran,Ilhan; Ulutin,Turgut; Hacihanefioglu,Seniha. Sister chromatid exchange (SCE) and chromosome aberrations (CA) in peripheral lymphocytes has been widely used in assessing exposure to mutagens and carcinogens. One of the extensively studied genotoxins is benzo[alpha]pyrene (BaP). We studied the ability of BaP to induce SCE and CA in 16 glutathione S-transferase M1 (GSTM1)-positive and 15 GSTM1-null individuals by analyzing 72-h whole-blood lymphocyte cultures, either BaP-untreated (controls) or treated with 5 µM of BaP for 24 or 48 h. There was no differences in the level of BaP-induced chromosomal aberrations between GSTM1-positive or null individuals when the cells were BaP-exposed for 24 h (0.083 ± 0.059 vs. 0.090 ± 0.058) or 48 h (0.092 ± 0.057 vs. 0.096 ± 0.050. The frequency of SCE in controls was... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sister chromatid exchanges; Chromosomal aberrations; Benzo[alpha]pyrene; Glutathione S-transferase M1. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000100027 Registros recuperados: 2 Primeira ... 1 ... Última

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