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Neutralizing potential of Rauvolfia serpentina root extract against Naja naja venom BJPS
Sivaraman,Thulasi; Sreedevi,Nadooparambil Sasi; Meenachisundharam,Subramani; Vadivelan,Ramachandran.
Snake bites are a serious health hazard occurs throughout the world especially in tropical countries like India. Anti-Snake Venom Serum is the only remedy available to treat snake bite victims successfully till date. Infusion of ASV may lead to adverse reactions ranging from severe itching of the skin, hives to potentially serious allergic reactions. Considering all above difficulties research workers all over the world is constantly in search of a cheap and readily available easy formulate remedy for treating snake bite victims. In present study aqueous extract of Rauvolfia serpentina root was checked for the antidote properties against Naja naja venom by in vitro and in vivo methods. Various in vitro neutralization tests like Acetyl cholinesterase,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Snake bite; Naja naja; Rauvolfia serpentina; Antivenom compounds.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100546
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THE IMPROVEMENT AND STANDARDIZATION OF ANTIVENOM PRODUCTION IN DEVELOPING COUNTRIES: COMPARING ANTIVENOM QUALITY, THERAPEUTICAL EFFICIENCY, AND COST J. Venom. Anim. Toxins
KRIFI,M. N.; EL AYEB,M.; DELLAGI,K..
The first antivenom was prepared by Calmette in 1894. More than a century later, it is still the only specific treatment for envenoming. The methods currently used by almost all antivenom producers worldwide to isolate and concentrate antivenom antibodies and their enzymatically derived fragments are improvements of those originally developed by Pope in 1938. Several new alternatives have been proposed to produce F(ab')2 or Fab antivenoms to improve their purity, neutralizing potency, and safety and to overcome the problems encountered in the production protocols based on ammonium sulfate precipitation of equine immunoglobulin. These include complete or partial modifications in the antivenom production regarding animal producers (ovine, laying hens...),...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antivenom; Standardization of antivenom; F(ab')2 and Fab antivenoms; Anaphylactic reaction; Anaphylactoid reaction; Snake bite; Scorpion sting.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301999000200002
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