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| Sousa,Neila C. de; Rezende,Alexandre A.A. de; Silva,Regildo M.G. da; Guterres,Zaira R.; Graf,Ulrich; Kerr,Warwick E.; Spanó,Mário A.. |
| The wing Somatic Mutation and Recombination Test (SMART) in D. melanogaster was used to study genotoxicity of the medicinal plant Tabebuia impetiginosa. Lapachol (naphthoquinone) and β-lapachone (quinone) are the two main chemical constituents of T. impetiginosa. These compounds have several biological properties. They induce apoptosis by generating oxygen-reactive species, thereby inhibiting topoisomerases (I and II) or inducing other enzymes dependent on NAD(P)H:quinone oxidoreductase 1, thus affecting cell cycle checkpoints. The SMART was used in the standard (ST) version, which has normal levels of cytochrome P450 (CYP) enzymes, to check the direct action of this compound, and in the high bioactivation (HB) version, which has a high constitutive level... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Genotoxicity; Synergistic effect; Somatic mutation and recombination test - SMART; Toxicity; Wing spot test. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200027 |
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