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	Provedor de dados BJMBR (2) Autor Chen,Xin (1) Dai,Dawei (1) Fan,B.F. (1) Jiang,Ying (1) Li,C.R. (1) Liu,B.T. (1) Lu,Youming (1) Mao,P. (1) Wang,Junyu (1) Yuan,Lei (1) Zhang,Aijun (1) Zhang,S.Z. (1) Zhang,Y. (1) Zou,Dongdong (1) Mais... Palavra-chave Neuropathic pain (2) Spared nerve injury (2) Dorsal root ganglion (1) Hypm gene (1) Long noncoding RNA (1) MicroRNAs (1) Transcriptome (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2018 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Transcriptomic differential lncRNA expression is involved in neuropathic pain in rat dorsal root ganglion after spared sciatic nerve injury BJMBR Mao,P.; Li,C.R.; Zhang,S.Z.; Zhang,Y.; Liu,B.T.; Fan,B.F.. Dorsal root ganglia (DRG) neurons regenerate spontaneously after traumatic or surgical injury. Long noncoding RNAs (lncRNAs) are involved in various biological regulation processes. Conditions of lncRNAs in DRG neuron injury deserve to be further investigated. Transcriptomic analysis was performed by high-throughput Illumina HiSeq2500 sequencing to profile the differential genes in L4–L6 DRGs following rat sciatic nerve tying. A total of 1,228 genes were up-regulated and 1,415 down-regulated. By comparing to rat lncRNA database, 86 known and 26 novel lncRNA genes were found to be differential. The 86 known lncRNA genes modulated 866 target genes subject to gene ontology (GO) and KEGG enrichment analysis. The genes involved in the neurotransmitter status of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Spared nerve injury; Neuropathic pain; Long noncoding RNA; Transcriptome; Hypm gene. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001000601 Small RNA sequencing reveals microRNAs related to neuropathic pain in rats BJMBR Dai,Dawei; Wang,Junyu; Jiang,Ying; Yuan,Lei; Lu,Youming; Zhang,Aijun; Zou,Dongdong; Chen,Xin. The present study aimed to identify microRNAs (miRNAs) that are involved in neuropathic pain and predict their corresponding roles in the pathogenesis and development process of neuropathic pain. The rat model of neuropathic pain caused by spared nerve injury (SNI) was established in Sprague-Dawley male rats, followed by small RNA sequencing of the L3–L6 dorsal root ganglion. Real-time PCR was performed to validate the differently expressed miRNAs. Functional verification was performed by intrathecally injecting the animals with miRNA agomir. A total of 72 differentially expressed miRNAs were identified in the SNI rats, including 33 upregulated and 39 downregulated miRNAs. The results of qPCR further verified the expression levels of rno-miR-6215... Tipo: Info:eu-repo/semantics/article Palavras-chave: MicroRNAs; Neuropathic pain; Spared nerve injury; Dorsal root ganglion. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001000602 Registros recuperados: 2 Primeira ... 1 ... Última

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