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	Provedor de dados 56 (2) Autor Borioli,G.A. (1) Coelho,J.C. (1) Del Boca,M. (1) Fanani,M.L. (1) Giugliani,R. (1) Maggio,B. (1) Rosetti,C.M. (1) Scalco,F.B. (1) Tobo,P. (1) Mais... Palavra-chave Sphingomyelinase (2) Anphitropic proteins (1) C-Fos (1) Cholesterol metabolism (1) Lipid monolayers (1) Lipid-protein interaction (1) Lysosomal storage disorders (1) Niemann-Pick disease (1) Segregated lipid domains (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2005 (1) 1999 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Protein-mediated surface structuring in biomembranes 56 Maggio,B.; Rosetti,C.M.; Borioli,G.A.; Fanani,M.L.; Del Boca,M.. The lipids and proteins of biomembranes exhibit highly dissimilar conformations, geometrical shapes, amphipathicity, and thermodynamic properties which constrain their two-dimensional molecular packing, electrostatics, and interaction preferences. This causes inevitable development of large local tensions that frequently relax into phase or compositional immiscibility along lateral and transverse planes of the membrane. On the other hand, these effects constitute the very codes that mediate molecular and structural changes determining and controlling the possibilities for enzymatic activity, apposition and recombination in biomembranes. The presence of proteins constitutes a major perturbing factor for the membrane sculpturing both in terms of its surface... Tipo: Info:eu-repo/semantics/article Palavras-chave: Lipid monolayers; Sphingomyelinase; C-Fos; Segregated lipid domains; Lipid-protein interaction; Anphitropic proteins. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200002 Effect of dimethylsulfoxide on sphingomyelinase activity and cholesterol metabolism in Niemann-Pick type C fibroblasts 56 Scalco,F.B.; Giugliani,R.; Tobo,P.; Coelho,J.C.. Niemann-Pick type C (NPC) fibroblasts present a large concentration of cholesterol in their cytoplasm due to a still unidentified deficiency in cholesterol metabolism. The influence of dimethylsulfoxide (DMSO) on the amount of intracellular cholesterol was measured in 8 cultures of normal fibroblasts and in 7 fibroblast cultures from NPC patients. DMSO was added to the fibroblast cultures at three different concentrations (1, 2 and 4%, v/v) and the cultures were incubated for 24 h. Sphingomyelinase activity was significantly increased in both groups of cells only when incubated with 2% DMSO (59.4 ± 9.1 and 77.0 ± 9.1 nmol h-1 mg protein-1, controls without and with 2% DMSO, respectively; 47.7 ± 5.2 and 55.8 ± 4.1 nmol h-1 mg protein-1, NPC without and with... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cholesterol metabolism; Sphingomyelinase; Niemann-Pick disease; Lysosomal storage disorders. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000100003 Registros recuperados: 2 Primeira ... 1 ... Última

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