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Development of granules from Phyllanthus niruri spray-dried extract 60
Souza,Tatiane Pereira de; Gómez-Amoza,José Luiz; Pacheco,Ramón Martínez; Petrovick,Pedro Ros.
The aim of this study was to develop granules from Phyllanthus niruri spray-dried extract using dry and wet granulation and to assess techniques to enable the production of granules with improved technological characteristics and yields. Granules were characterized by granulometry, reological parameters, compression and hygroscopic behavior. Independent of the granulation technique, technologically developed granules presented particle diameter, bulk and tapped densities and compressibility indexes suitable for a solid dosage form. The compression behavior showed plastic and fragmentary deformation for granules produced by the dry granulation technique and predominantly plastic deformation for wet granulation. Concerning the humidity sorption, the study...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Phyllantus nururi/pharmacotechnics; Granules/production; Spray-dried extract; Wet granulation; Dry granulation.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000400009
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Development of enteric coated tablets from spray dried extract of feverfew (Tanacetum parthenium L: ) 60
Chaves,Juliana Siqueira; Da Costa,Fernando Batista; Freitas,Luís Alexandre Pedro de.
Tanacetum parthenium (feverfew) is an herb that is commercialized worldwide as a therapeutic treatment for migraine. Its pharmacological effect is mainly due to the presence of the sesquiterpene lactone parthenolide as well as of flavonoids. So far, there are no studies on standardization of pre-formulations or phytomedicines containing this herb. The present study aimed at developing a pre-formulation using a standardized spray-dried extract of feverfew and further designing and standardizing enteric coated tablets. In this work, the spray-dried extract of feverfew was evaluated for its parthenolide, santin and total flavonoid content, parthenolide solubility, particle size, tapped density, hygroscopicity, angle of repose and moisture content. Tablets...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Enteric coated tablets; Flavonoids; Parthenolide; Phytomedicine; Spray-dried extract; Tanacetum parthenium.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300024
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