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Effect of stearic acid on the properties of metronidazole/methocel K4M floating matrices BJPS
Lara-Hernández,Belem; Hernández-León,Alejandra; Villafuerte-Robles,Leopoldo.
The properties of metronidazole/Methocel K4M sustained release floating tablets have been studied varying the proportion of the lubricant, stearic acid, on formulations with and without sodium bicarbonate. The variables studied include technological properties of the tablets such as tablet hardness and ejection pressure, the drug release profile, the hydration kinetics and the floating behaviour. The presence of stearic acid and sodium bicarbonate improves the floating behaviour for more than 8 hours. The hydration volume, the tablet hardness and the ejection pressure decrease as the stearic acid content increases and the polymer content decreases. Drug dissolution increases with increasing proportions of stearic acid and decreasing proportions of the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Metronidazole; Methocel K4M; Stearic acid; Matrices hydration; Gastric retention; Sodium bicarbonate; Sustained release; Drugs/release mechanism.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300016
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Comparative study of sustained-release lipid microparticles and solid dispersions containing ibuprofen BJPS
Almeida,Hugo; Amaral,Maria Helena; Lobão,Paulo.
Ibuprofen is one of the most important non-steroidal anti-inflammatory drugs used in the treatment of inflammatory diseases. In its pure state, ibuprofen presents poor physical and mechanical characteristics and its use in solid dosage forms needs the addition of excipients that improve these properties. The selection of the best excipients and the most suitable pharmaceutical dosage form to carry ibuprofen is very important for the industrial success of this drug. Given these factors, lipid microparticles and solid dispersions of ibuprofen with cetyl alcohol, stearic acid, and hydrogenated castor oil were prepared. These formulations were intended to improve the physical and mechanical characteristics and to sustain the release of this drug. Physical...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ibuprofen/solid dispersions; Ibuprofen/release profile; Ibuprofen/lipid microparticles; Ibuprofen/release profile; Excipients; Cetyl alcohol; Stearic acid; Hydrogenated castor oil.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000300020
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Use of solid dispersions to increase stability of dithranol in topical formulations BJPS
Estanqueiro,Marilene; Conceição,Jaime; Amaral,Maria Helena; Lobo,José Manuel Sousa.
The present study was planned to improve the stability of dithranol using solid dispersions (SD). Two different SD at a 1:9 ratio of dithranol/excipient were prepared: one of them using glyceryl behenate as excipient and the other using a mixture of argan oil with stearic acid (1:8 ratio) as excipient. Pure dithranol and SD of dithranol were incorporated in an oil-in-water cream and in a hydrophobic ointment in a drug/dermatological base ratio of 1:10. The physical and mechanical properties of semisolid formulations incorporating the pure drug and the developed SD were evaluated through rheological and textural analysis. To evaluate the stability, L*a*b* color space parameters of SD and semisolid formulations, and pH of hydrophilic formulations were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dithranol/stability; Topical formulations/development; Solid dispersions/preparation; Stearic acid; Glyceryl behenate; Argan oil.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300583
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Effect of adding fatty acids and surfactant on the functional properties of biodegradable films prepared with myofibrillar proteins from acoupa weakfish (Cynoscion acoupa ) Ciênc. Tecnol. Aliment.
PEREIRA,Gleice Vasconcelos da Silva; PEREIRA,Glauce Vasconcelos da Silva; NEVES,Eleda Maria Paixão Xavier; JOELE,Maria Regina Sarkis Peixoto; LIMA,Consuelo Lúcia Sousa de; LOURENÇO,Lúcia de Fátima Henriques.
Abstract This research aimed to assess the properties of biodegradable films prepared with lyophilized myofibrillar proteins (LMP) from fish filleting residues, fatty acids (stearic, palmitic, and caproic), and surfactant (SLS). The films were characterized to assess the effects of adding those components. Adding fatty acids and SLS resulted in more flexible films with higher elongation values compared to the LMP film. The films prepared with 5% stearic acid and 10% SLS and with 10% palmitic acid and 20% SLS had higher tensile strength compared to the LMP film. Solubility reached 100% in the films added with 10% fatty acids with and without SLS. Increasing the concentration of fatty acids and SLS led to less transparent films. Microscopy analysis showed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Myofibrillar protein film; Compound film; Stearic acid; Palmitic acid; Caproic acid; Sodium lauryl sulfate.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612019000500287
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Qualidade do óleo extraído de aquênios de girassol produzidos na região Nordeste do Brasil. Infoteca-e
CARVALHO, C. G. P.; MAZZOLA, L. F.; CARVALHO, L. M. de; CARVALHO, H. W. L. de; MANDARINO, J. M. G.; DRUMOND, M. A.; SILVA, M. R. da.
Tipo: Folhetos Palavras-chave: Helianthus Annuus; Girassol; Ácido Linoléico; Óleo Vegetal; Sunflower oil; Palmitic acid; Linoleic acid; Oleic acid; Stearic acid; Vegetable oil.
Ano: 2019 URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/1115408
Registros recuperados: 5
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