|
|
|
|
| |
|
|
| Dutta,Noton K.; Dastidar,Sujata G.; Kumar,Asok; Mazumdar,Kaushiki; Ray,Raja; Chakrabarty,Atindra N.. |
| Diclofenac sodium, an antiinflammatory agent, exhibited remarkable inhibitory action against both drug sensitive and drug resistant clinical isolates of Mycobacterium tuberculosis, as well as other mycobacteria. This drug was tested in vitro against 45 different strains of mycobacteria, most of which were inhibited by the drug at 10-25 µg/ml concentration. When tested in vivo, diclofenac, injected at 10 µg/g body weight of a Swiss strain of white mice, could significantly protect them when challenged with 50 median lethal dose of M. tuberculosis H37 Rv 102. According to chi2 test, the in vivo data were highly significant (p<0.01). Diclofenac was further tested for synergism with the conventional antimycobacterial drug streptomycin against M. smegmatis... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antiinflammatory drug; Diclofenac sodium; Antimycobacterial activity; Streptomycin; Synergism; Non-antibiotic. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822004000300009 |
| |
|
|
| Araújo,Sthéfane G.; Alves,Lucas F.; Pinto,Maria Eduarda A.; Oliveira,Graziela T.; Siqueira,Ezequias P.; Ribeiro,Rosy I. M. A.; Ferreira,Jaqueline M. S.; Lima,Luciana A. R. S.. |
| Bacterial infections cause thousands of deaths in the world every year. In most cases, infections are more serious because the patient is already weakened, and often, the bacteria are already resistant to the antibiotics used. Counterparting this negative scenario, the interest in medicinal plants as an alternative to the synthetic antimicrobial drugs is blossoming worldwide. In the present work, we identified the volatile compounds of ethanol extracts of Melissa officinalis, Mentha sp., Ocimum basilicum, Plectranthus barbatus, and Rosmarinus officinalis by gas chromatography/mass spectrometry (GC/MS). Also was evaluated antimicrobial activity of ethanol extracts against 6 bacteria of clinical interest, and was tested the interaction of these extracts with... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lamiaceae; Antibacterial; Ethanol extracts; Volatile compounds; Streptomycin. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000400026 |
| |
|
|
|
