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	Provedor de dados BJPS (2) Autor Avasarala,Harani (1) Banji,David (1) Dinakaran,Sathis Kumar (1) Hernández-León,Alejandra (1) Kumar,Santhos (1) Lara-Hernández,Belem (1) Rao,Venkateshwar (1) Villafuerte-Robles,Leopoldo (1) Mais... Palavra-chave Sustained release (2) Bi-layer tablet (1) Drugs/release mechanism (1) Gastric retention (1) Matrices hydration (1) Methocel K4M (1) Metronidazole (1) Sodium bicarbonate (1) Stearic acid (1) Trihexyphenidyl HCl (1) Ziprasidone HCl (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2011 (1) 2009 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Effect of stearic acid on the properties of metronidazole/methocel K4M floating matrices BJPS Lara-Hernández,Belem; Hernández-León,Alejandra; Villafuerte-Robles,Leopoldo. The properties of metronidazole/Methocel K4M sustained release floating tablets have been studied varying the proportion of the lubricant, stearic acid, on formulations with and without sodium bicarbonate. The variables studied include technological properties of the tablets such as tablet hardness and ejection pressure, the drug release profile, the hydration kinetics and the floating behaviour. The presence of stearic acid and sodium bicarbonate improves the floating behaviour for more than 8 hours. The hydration volume, the tablet hardness and the ejection pressure decrease as the stearic acid content increases and the polymer content decreases. Drug dissolution increases with increasing proportions of stearic acid and decreasing proportions of the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Metronidazole; Methocel K4M; Stearic acid; Matrices hydration; Gastric retention; Sodium bicarbonate; Sustained release; Drugs/release mechanism. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300016 Formulation and evaluation of bi-layer floating tablets of ziprasidone HCl and trihexyphenidyl HCl BJPS Dinakaran,Sathis Kumar; Kumar,Santhos; Banji,David; Avasarala,Harani; Rao,Venkateshwar. The purpose of this research study was to establish ziprasidone HCl NR 40 mg and trihexyphenidyl HCl SR 4mg in the form of bi-layer sustained release floating tablets. The tablets were prepared using sodium HPMC K4M / HPMC K15M as bio-adhesive polymers and sodium bicarbonate acting as a floating layer. Tablets were evaluated based on different parameters such as thickness, hardness, friability, weight variation, in vitro dissolution studies, content of active ingredient and IR studies. The physico-chemical properties of the finished product complied with the specifications. In vitro release from the formulation was studied as per the USP XXIII dissolution procedure. The formulations gave a normal release effect followed by sustained release for 12 h which... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bi-layer tablet; Ziprasidone HCl; Trihexyphenidyl HCl; Sustained release. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300012 Registros recuperados: 2 Primeira ... 1 ... Última

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