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| Sousa,Neila C. de; Rezende,Alexandre A.A. de; Silva,Regildo M.G. da; Guterres,Zaira R.; Graf,Ulrich; Kerr,Warwick E.; Spanó,Mário A.. |
| The wing Somatic Mutation and Recombination Test (SMART) in D. melanogaster was used to study genotoxicity of the medicinal plant Tabebuia impetiginosa. Lapachol (naphthoquinone) and β-lapachone (quinone) are the two main chemical constituents of T. impetiginosa. These compounds have several biological properties. They induce apoptosis by generating oxygen-reactive species, thereby inhibiting topoisomerases (I and II) or inducing other enzymes dependent on NAD(P)H:quinone oxidoreductase 1, thus affecting cell cycle checkpoints. The SMART was used in the standard (ST) version, which has normal levels of cytochrome P450 (CYP) enzymes, to check the direct action of this compound, and in the high bioactivation (HB) version, which has a high constitutive level... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Genotoxicity; Synergistic effect; Somatic mutation and recombination test - SMART; Toxicity; Wing spot test. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200027 |
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| Feng,Yi-Jun; Feng,Qi; Tao,Jie; Zhao,Rong; Ji,Yong-Hua. |
| AbstractBackground BmK I, a site-3-specific modulator of voltage-gated sodium channels (VGSCs), causes pain and hyperalgesia in rats, while BmK IT2, a site-4-specific modulator of VGSCs, suppresses pain-related responses. A stronger pain-related effect has been previously attributed to Buthus martensi Karsch (BmK) venom, which points out the joint pharmacological effect in the crude venom.Methods In order to detect the joint effect of BmK I and BmK IT2 on ND7-23 cells, the membrane current was measured by whole cell recording. BmK I and BmK IT2 were applied successively and jointly, and the synergistic modulations of VGSCs on ND7-23 cells were detected.Results Larger peak I Na and more negative half-activation voltage were elicited by joint application of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: BmK I; BmK IT2; Synergistic effect; Allosteric interactions. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992015000100347 |
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