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| Gonzalez,Ramon. |
| Metabolic engineering was formally defined more than two decades ago (Bailey, 1991) and it is now an established discipline. Metabolic engineering is generally defined as the directed improvement of product formation or cellular properties through the modification of specific biochemical reactions or the introduction of new ones with the use of recombinant DNA technology (Bailey, 1991; Stephanopoulos et al. 1998). Therefore, the analysis and engineering/synthesis of metabolic pathways is of central importance to metabolic engineering. The analytical part uses a number of experimental and modeling techniques for the systematic study of cellular responses (in terms of RNA, protein and metabolite levels, metabolic fluxes, etc.) to genetic and environmental... |
| Tipo: Journal article |
Palavras-chave: Biofuels; Escherichia coli; Metabolic engineering; Systems biology. |
| Ano: 2013 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582013000300017 |
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| Corrêa,Thiago; Feltes,Bruno César; Riegel,Mariluce. |
| Abstract Cri-du-chat syndrome (CdCs) is one of the most common contiguous gene syndromes, with an incidence of 1:15,000 to 1:50,000 live births. To better understand the etiology of CdCs at the molecular level, we investigated theprotein–protein interaction (PPI) network within the critical chromosomal region 5p15.3–p15.2 associated with CdCs using systemsbiology. Data were extracted from cytogenomic findings from patients with CdCs. Based on clinical findings, molecular characterization of chromosomal rearrangements, and systems biology data, we explored possible genotype–phenotype correlations involving biological processes connected with CdCs candidate genes. We identified biological processes involving genes previously found to be associated with CdCs,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cri-du-Chat Syndrome; 5p– cytogenomics; Integrative Analysis; PPI; Systems biology. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000200186 |
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| Moalic, Yann; Desbruyeres, Daniel; Duarte, Carlos M.; Rozenfeld, Alejandro F.; Bachraty, Charleyne; Arnaud-haond, Sophie. |
| Defining biogeographic provinces to understand the history and evolution of communities associated with a given kind of ecosystem is challenging and usually requires a priori assumptions to be made. We applied network theory, a holistic and exploratory method, to the most complete database of faunal distribution available on oceanic hydrothermal vents, environments which support fragmented and unstable ecosystems, to infer the processes driving their worldwide biogeography. Besides the identification of robust provinces, the network topology allowed us to identify preferential pathways that had hitherto been overlooked. These pathways are consistent with the previously proposed hypothesis of a role of plate tectonics in the biogeographical history of... |
| Tipo: Text |
Palavras-chave: Biogeography; Deep sea ecology; Hydrothermal vents; Network analysis; Systems biology. |
| Ano: 2012 |
URL: http://archimer.ifremer.fr/doc/00063/17400/15164.pdf |
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