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| Simon,Thomas; Tanguy-Royer,Séverine; Royer,Pierre-Joseph; Boisgerault,Nicolas; Frikeche,Jihane; Fonteneau,Jean-François; Grégoire,Marc. |
| Dendritic cells (DCs) are professional antigen-presenting cells involved in the control and initiation of immune responses. In vivo, DCs exposed at the periphery to maturation stimuli migrate to lymph nodes, where they receive secondary signals from CD4+ T helper cells. These DCs become able to initiate CD8+ cytotoxic T lymphocyte (CTL) responses. However, in vitro investigations concerning human monocyte-derived DCs have never focused on their functional properties after such sequential maturation. Here, we studied human DC phenotypes and functions according to this sequential exposure to maturation stimuli. As first signals, we used TNF-α/polyI:C mimicking inflammatory and pathogen stimuli and, as second signals, we compared activated CD4+ T... |
| Tipo: Journal article |
Palavras-chave: Cytotoxic T lymphocytes; Dendritic cells; T memory cell; Sequential maturation. |
| Ano: 2012 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000100005 |
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