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	Provedor de dados BJMBR (3) Autor Casseb,J. (1) Domínguez,M.C. (1) García-Vallejo,F. (1) Penalva-de-Oliveira,A.C. (1) Tamayo,O. (1) Zaninovic',V. (1) Mais... Palavra-chave TSP/HAM (3) HTLV-I (2) Astrocytes (1) Cassava (1) Cycads (1) Glutamate (1) Human T-cell leukemia type I-associated myelopathy (1) Molecular mimicry (1) Paradoxical epidemiology (1) Retrovirus (1) Toxic and toxoviral etiologies (1) Tropical spastic paraparesis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2005 (1) 2004 (1) 2000 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Possible etiologies for tropical spastic paraparesis and human T lymphotropic virus I-associated myelopathy BJMBR Zaninovic',V.. The epidemiology of tropical spastic paraparesis/human T lymphotropic virus I (HTLV-I)-associated myelopathy (TSP/HAM) is frequently inconsistent and suggests environmental factors in the etiology of these syndromes. The neuropathology corresponds to a toxometabolic or autoimmune process and possibly not to a viral disease. Some logical hypotheses about the etiology and physiopathology of TSP and HAM are proposed. Glutamate-mediated excitotoxicity, central distal axonopathies, cassava, lathyrism and cycad toxicity may explain most cases of TSP. The damage caused to astrocytes and to the blood-brain barrier by HTLV-I plus xenobiotics may explain most cases of HAM. Analysis of the HTLV-I/xenobiotic ratio clarifies most of the paradoxical epidemiology of TSP... Tipo: Info:eu-repo/semantics/article Palavras-chave: TSP/HAM; Paradoxical epidemiology; Toxic and toxoviral etiologies; HTLV-I; Glutamate; Astrocytes; Cycads; Cassava. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000100001 The pathogenesis of tropical spastic paraparesis/human T-cell leukemia type I-associated myelopathy BJMBR Casseb,J.; Penalva-de-Oliveira,A.C.. Tropical spastic paraparesis/human T-cell leukemia type I-associated myelopathy (TSP/HAM) is caused by a human T-cell leukemia virus type I (HTLV-I) after a long incubation period. TSP/HAM is characterized by a chronic progressive paraparesis with sphincter disturbances, no/mild sensory loss, the absence of spinal cord compression and seropositivity for HTLV-I antibodies. The pathogenesis of this entity is not completely known and involves a multivariable phenomenon of immune system activation against the presence of HTLV-I antigens, leading to an inflammatory process and demyelination, mainly in the thoracic spinal cord. The current hypothesis about the pathogenesis of TSP/HAM is: 1) presence of HTLV-I antigens in the lumbar spinal cord, noted by an... Tipo: Info:eu-repo/semantics/article Palavras-chave: Tropical spastic paraparesis; Human T-cell leukemia type I-associated myelopathy; TSP/HAM. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001200001 Autoimmunity and molecular mimicry in tropical spastic paraparesis/human T-lymphotropic virus-associated myelopathy BJMBR García-Vallejo,F.; Domínguez,M.C.; Tamayo,O.. Viruses share antigenic sites with normal host cell components, a phenomenon known as molecular mimicry. It has long been suggested that viral infections might trigger an autoimmune response by several mechanisms including molecular mimicry. More than 600 antiviral monoclonal antibodies generated against 11 different viruses have been reported to react with 3.5% of cells specific for uninfected mouse organs. The main pathological feature of tropical spastic paraparesis/human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (TSP/HAM) is a chronic inflammation of the spinal cord characterized by perivascular cuffing of mononuclear cells accompanied by parenchymal lymphocytic infiltration. We detected the presence of autoantibodies against a 98- to... Tipo: Info:eu-repo/semantics/article Palavras-chave: HTLV-I; TSP/HAM; Retrovirus; Molecular mimicry. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000200013 Registros recuperados: 3 Primeira ... 1 ... Última

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