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Role of Tamm-Horsfall protein and uromodulin in calcium oxalate crystallization BJMBR
Carvalho,M.; Mulinari,R.A.; Nakagawa,Y..
One of the defenses against nephrolithiasis is provided by macromolecules that modulate the nucleation, growth, aggregation and retention of crystals in the kidneys. The aim of the present study was to determine the behavior of two of these proteins, Tamm-Horsfall and uromodulin, in calcium oxalate crystallization in vitro. We studied a group of 10 male stone formers who had formed at least one kidney stone composed of calcium oxalate. They were classified as having idiopathic nephrolithiasis and had no well-known metabolic risk factors involved in kidney stone pathogenesis. Ten normal men were used as controls, as was a group consisting of five normal women and another consisting of five pregnant women. Crystallization was induced by a fixed...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tamm-Horsfall protein; Uromodulin; Calcium oxalate; Nephrolithiasis.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000009
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Effect of an isotonic rehydration sports drink and exercise on urolithiasis in rats BJMBR
Abreu,N.P.; Bergamaschi,C.T.; di Marco,G.S.; Razvickas,C.V.; Schor,N..
The objective of the present study was to evaluate the role of physical exercise as well as the influence of hydration with an isotonic sports drink on renal function in male Wistar rats. Four groups were studied over a period of 42 days: 1) control (N = 9); 2) physical exercise (Exe, N = 7); 3) isotonic drink (Drink, N = 8); 4) physical exercise + isotonic drink (Exe + Drink, N = 8). Physical exercise consisted of running on a motor-driven treadmill for 1 h/day, at 20 m/min, 5 days a week. The isotonic sports drink was a commercial solution used by athletes for rehydration after physical activity, 2 ml administered by gavage twice a day. Urine cultures were performed in all animals. Twenty-four-hour urine samples were collected in metabolic cages at the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Renal function; Isotonic rehydration sports drink; Physical activity; Renal stone; Nephrolithiasis; Tamm-Horsfall protein.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000400011
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Role of Tamm-Horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated Escherichia coli by mouse peritoneal macrophages BJMBR
Bastos,A.C.S.C.; Santos,L.B.; Tamashiro,W.M.S.C.; Yamada,A.T.; Oliveira,U.M.; Yano,T..
Tamm-Horsfall glycoprotein (THP) contains manno-oligosaccharides that are recognized by type 1 fimbriae (F1) of Escherichia coli. In the present study, we examined the in vivo phagocytic activity of mouse peritoneal macrophages after treatment of bacteria with THP. At low THP concentrations (12.5 µg/ml and 50 µg/ml) no significant difference was observed in the phagocytosis of E. coli F1+. However, at high THP concentrations (500 µg/ml and 1250 µg/ml) we obtained a reduction of bacterial phagocytosis by mouse peritoneal macrophages.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tamm-Horsfall protein; Type 1 fimbriated E. coli; Phagocytosis.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000700011
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