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	Provedor de dados BJPS (1) Autor Al-Dhubiab,Bandar (1) Attimarad,Mahesh (1) Harsha,Sree (1) Jacob,Shery (1) Nair,Anroop (1) Palavra-chave Dermatokinetics (1) Dermatological formulations/pharmacokinetics (1) Dermatological formulations/toxicity (1) Microdialysis (1) Skin/metabolism (1) Tape stripping (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2013 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Basic considerations in the dermatokinetics of topical formulations BJPS Nair,Anroop; Jacob,Shery; Al-Dhubiab,Bandar; Attimarad,Mahesh; Harsha,Sree. Assessing the bioavailability of drug molecules at the site of action provides better insight into the efficiency of a dosage form. However, determining drug concentration in the skin layers following topical application of dermatological formulations is a great challenge. The protocols followed in oral formulations could not be applied for topical dosage forms. The regulatory agencies are considering several possible approaches such as tape stripping, microdialysis etc. On the other hand, the skin bioavailability assessment of xenobiotics is equally important for topical formulations in order to evaluate the toxicity. It is always possible that drug molecules applied on the skin surface may transport thorough the skin and reaches systemic circulation.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Dermatological formulations/pharmacokinetics; Dermatological formulations/toxicity; Dermatokinetics; Skin/metabolism; Microdialysis; Tape stripping. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300004 Registros recuperados: 1 Primeira ... 1 ... Última

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