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Chlorpheniramine impairs functional recovery in Carassius auratus after telencephalic ablation BJMBR
Garção,D.C.; Canto-de-Souza,L.; Romaguera,F.; Mattioli,R..
We determined the effect of an H1 receptor antagonist on the functional recovery of Carassius auratus submitted to telencephalic ablation. Five days after surgery the fish underwent a spatial-choice learning paradigm test. The fish, weighing 6-12 g, were divided into four groups: telencephalic ablation (A) or sham lesion (S) and saline (SAL) or chlorpheniramine (CPA, ip, 16 mg/kg). For eight consecutive days each animal was trained individually in sessions separated by 24 h (alternate days). Training trials (T1-T8) consisted of finding the food in one of the feeders, which were randomly blocked for each subject. Animals received an intraperitoneal injection of SAL or CPA 10 min after the training trials. The time spent by the animals in each group to find...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Functional recovery; Spatial-choice learning; Histamine; Chlorpheniramine; Carassius auratus; Telencephalic ablation.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000400010
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Chlorpheniramine facilitates inhibitory avoidance in teleosts submitted to telencephalic ablation BJMBR
Faganello,F.R.; Mattioli,R..
The present study investigated the involvement of H(1) histaminegic receptor on the acquisition of inhibitory avoidance in Carassius auratus submitted to telencephalic ablation. The fish were submitted to telencephalic ablation 5 days before the experiment. The inhibitory avoidance procedure included 1 day for habituation, 3 days for training composed of 3 trials each (1st day: T1, T2, T3; 2nd day: 2T1, 2T2, 2T3; 3rd day: 3T1, 3T2, 3T3) and 1 day for test. On training days, the fish were placed in a white compartment, after 30 s the door was opened. When the fish crossed to a black compartment, a weight was dropped (aversive stimuli). Immediately after the third trial, on training days, the fish received, intraperitoneally, one of the pharmacological...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Chlorpheniramine; Inhibitory avoidance; Telencephalic ablation; Teleost.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000500008
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