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Computer simulations for biological aging and sexual reproduction Anais da ABC (AABC)
STAUFFER,DIETRICH; OLIVEIRA,PAULO M.C. DE; OLIVEIRA,SUZANA MOSS DE; PENNA,THADEU J.P.; MARTINS,JORGE S. SÁ.
The sexual version of the Penna model of biological aging, simulated since 1996, is compared here with alternative forms of reproduction as well as with models not involving aging. In particular we want to check how sexual forms of life could have evolved and won over earlier asexual forms hundreds of million years ago. This computer model is based on the mutation-accumulation theory of aging, using bits-strings to represent the genome. Its population dynamics is studied by Monte Carlo methods.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Parthenogenesis; Genome; Menopause; Testosterone; Monte Carlo simulation.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652001000100003
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Morphometry and histomorphometry of the testis in crossbred pigs fed diets with different protein levels Arq. Bras. Med. Vet. Zootec.
Valença,R.M.B.; Silva Junior,V.A.; Araújo,L.P.C.; Reis,J.C.; Guerra,M.M.P.; Soares,P.C.; Costa,A.N..
Aiming to evaluate the effect of the diet protein content on testicular parameters in pigs, 21 non-gelded male Dalland pigs were used and randomly divided into three groups. Males belonging to groups G2 and G3 received a diet with crude protein levels of 15% below and above, respectively, in relation to G1 (control). At 210 days of age, animals were castrated, and testis and epididymis were collected for morphometric and histomorphometry analyses. No difference was observed in relation to the total length of seminiferous tubules (G1=3239.9±333,3m; G2=2989.4±171,7m and G3=3059.5±254.9m), population of Sertoli cell (G1=4.7±0.5x10(9); G2=4.3±0.3x10(9) and G3=4.7±0.5x10(9)), population (G1=31.6±5.58x10(9); G2=27.3±4.0x10(9) and G3=26.4±3.9x10(9)) and volume of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pigs; Sperm production; Sertoli cells; Protein; Testosterone.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352013000500010
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Integrity of the plasma membrane, the acrosomal membrane, and the mitochondrial membrane potential of sperm in Nelore bulls from puberty to sexual maturity Arq. Bras. Med. Vet. Zootec.
Reis,L.S.L.S.; Ramos,A.A.; Camargos,A.S.; Oba,E..
ABSTRACT This study evaluated the plasma membrane integrity, acrosomal membrane integrity, and mitochondrial membrane potential of Nelore bull sperm from early puberty to early sexual maturity and their associations with sperm motility and vigor, the mass motility of the spermatozoa (wave motion), scrotal circumference, and testosterone. Sixty Nelore bulls aged 18 to 19 months were divided into four lots (n=15 bulls/lot) and evaluated over 280 days. Semen samples, collected every 56 days by electroejaculation, were evaluated soon after collection for motility, vigor and wave motion under an optical microscope. Sperm membrane integrity, acrosomal integrity, and mitochondrial activity were evaluated under a fluorescent microscope using probe association...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sexual development; Sperm motility; Sperm vigor; Testosterone; Cattle.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352016000300620
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Testosterone level, nasal gland volume and Leydig cell morphometry in capybaras (Hydrochoerus hydrochaeris) Arq. Bras. Med. Vet. Zootec.
Costa,D.S.; Paula,T.A.R..
The testosterone levels with nasal gland volume and Leydig cell morphometry in sexually mature capybaras were compared using 10 adult capybaras, aging 28 months. Body and testicular weight were 50kg and 28g, respectively. The gonadosomatic index was 0.11±0.02%, while nasal gland volume was 34.12±13.04ml. Serum testosterone concentration was 25.07±14.73ng/ml. Leydig cell volume density and leydigosomatic index were, respectively, 28.8±8.3% and 0.030±0.007%. Total and individual Leydig cell volumes were 6.88±1.92ml and 2,228.14±272.59x10-12ml, respectively. Leydig cell numbers per testis and per gram of testis were, respectively, 3,079.4±719.9x10(6) and 115.09±31.78x10(6) cells. These results show that increase in serum testosterone concentration is...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Capybara; Testosterone; Morphometry; Leydig cells; Nasal gland.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352006000600017
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Effects of prenatal stress on male offspring sexual maturity Biocell
Rodríguez,Nancy; Mayer,Nora; Gauna,Héctor F.
Prenatal stimulations have been shown to have long-term effects on at reproductive activity. We evaluated the influence of the prenatal stress on the hypothalamic-pituitary-gonad (HPG) axis in male off­springs from mothers with high number of offsprings per litter (HNL) and low number of offsprings per litter (LNL) after hypothesizing that the number of offsprings per litter may modify the effect of the prenatal stress on the HPG of adult offsprings. Pregnant Wistar rats were used for this study. Immobilization (IMO) stress was used, 30 min, 3 times per week, from the 5th to 21st day of pregnancy. The weight of adrenal and gonads, and the corticosterone (COR), testosterone (TES) and luteinizing hormone (LH) plasmatic levels were analyzed in the male...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rats; Prenatal stress; Reproduction; Corticosterone; Testosterone.
Ano: 2007 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452007000100008
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Association of the infusion of Heteropterys aphrodisiaca and endurance training brings spermatogenetic advantages Biol. Res.
Gomes,Marcos L M; Monteiro,Juliana C; Freitas,Karine M; Sbervelheri,Mariana M; Dolder,Heidi.
The species Heteropterys aphrodisiaca is commonly used as a stimulant by popular medicine in the Cerrado, a savanna-like biome, Brazil. Recent studies have proved its protective effects on testes of animals submitted to treatment using Cyclosporine A, as well as its stimulus effect in increasing testosterone secretion. Therefore, the present study was designed to analyze whether the association of the plant infusion and endurance exercise could potentiate the stimulating effect. The animals were separated into 4 groups: two control (sedentary and trained) receiving water and two treated (sedentary and trained) receiving the plant infusion daily (104mg/day). The proportion of the seminiferous tubule compartment and interstitium was analyzed. Within the...
Tipo: Journal article Palavras-chave: Germ cells; Phytotherapy; Seminiferous epithelium; Spermatogenesis; Testosterone.
Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000300004
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Possible link of different slow calcium signals generated by membrane potential and hormones to differential gene expression in cultured muscle cells Biol. Res.
JAIMOVICH,ENRIQUE; ESPINOSA,ALEJANDRA.
We studied the effect of IGF-I, insulin and testosterone on intracellular Ca2+ in cultured muscle cells. Insulin produced a fast (<1 s) and transient [Ca2+] increase lasting less than 10 s. IGF-I induced a transient [Ca2+] increase, reaching a fluorescence peak 6 s after stimulus, to return to basal values after 60 s. Testosterone induced delayed (35 s) and long lasting (100-200 s) signals, frequently associated with oscillations. IGF-I, testosterone and electrical stimulation-induced Ca2+ signals were shown to be dependent on IP3 production. All of these Ca2+ signals were blocked by inhibitors of the IP3 pathway. On the other hand, insulin-induced Ca2+ increase was dependent on ryanodine receptors and blocked by either nifedipine or ryanodine. The...
Tipo: Journal article Palavras-chave: Skeletal; Transcription factors; Insulin; IGF-I; Testosterone.
Ano: 2004 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400018
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Ameliorative Effects of Thymoquinone on Sperm Parameters and Testosterone Level of Nicotine-Treated Sprague Dawley Rats BABT
Rosli,Farah Dayana; Hashim,Noor Hashida; Osman,Khairul; Ibrahim,Siti Fatimah; Kabir,Nurul.
Abstract Thymoquinone (TQ), the main constituent of the volatile oil derived from Nigella sativa has shown pharmacological benefits against various diseases while nicotine is an active component in cigarette that is known to be detrimental. This study was conducted to assess the ameliorating effects of TQ on sperm count, membrane, mitochondria and testosterone of nicotine-treated rats. Rats were randomized into four groups: control, nicotine, TQ, and nicotine with TQ. Nicotine (5 mg/kg bwt/day) was subcutaneously injected for 30 days to induce damaging effects on sperm and testosterone level. Rats were force-fed with TQ (5 mg/kg bwt/day) for the following 30 days. Sperm count was reduced in the nicotine group (26.72 ± 1.64 106/mL) but showed a...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Thymoquinone; Nicotine; Rat sperm; Membrane; Mitochondria; Testosterone.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132019000100304
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Effect of Intermittent Feeding on Gonadal Function in Male And Female NMRI Mice During Chronic Stress BABT
Ehteram,Badri Zarrin; Sahraei,Hedayat; Meftahi,Gholam Hossein; Khosravi,Maryam.
ABSTRACT Stress can inhibit gonadal activity via Hypothalamus-Pituitary-Gonad (HPG) axis activity suppression. In the present study, effects of intermittent feeding (IF) on gonadal function under stress in male and female mice were evaluated. Twenty eight male and twenty eight female mice's were divided into four groups. The control group received adequate food and water without stress. The second group received four days of electric shock without food deprivation. The third group was deprived of food two hours/day for a week, and the fourth group was deprived of food (2 hours/day for seven consecutive days) and then electric foot shock stress was applied to them for four days. Blood samples were collected from all animals for plasma testosterone, estrogen...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Estrogen; Gonad; IL-6; Intermittent Feeding; Stress; Testosterone.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100439
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Testosterone concentration in a bovine Bos indicus with bilateral varicocele: case report Braz. J. Vet. Res. Anim. Sci.
Koivisto,Marion Burkhardt; Luvizotto,Maria Cristina Rui; Nogueira,Guilherme Padua; Vicente,Wilter Ricardo Russiano; Costa,Marcelo Tadeu Alvarenga.
A bovine, Bos indicus, with bilateral varicocele diagnosticed by palpation and ultrasound observation was observed during 24 months measuring scrotal circumference, semen quality, testosterone concentrations comparing with seasonal variation and other animals of the same species. The abnormal morphology of major defects and minor defects didn't change between the bull and the other animals, however, the total defects were higher during the summer in the bull with varicocele (49,9%±6,9) when compared with the other bulls (27,9%±2,9). The animal showed higher percentage of major defects during the summer, comparing with the other seasons of the year. For the animal with varicocele testosterone levels were significantly higher during the different season's of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Varicocele; Bovine; Semen; Testosterone; Bos indicus.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-95962002000100005
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Reproductive characteristics of captive male jaguars (Panthera onca) Braz. J. Vet. Res. Anim. Sci.
MORATO,Ronaldo Gonçalves; GUIMARÃES,Marcelo Alcindo Barros de Vaz; FERREIRA,Fernando; VERRESCHI,Ieda Terezinha do Nascimento; BARNABE,Renato Campanarut.
Ejaculate traits, testicular volume and plasma testosterone levels were determined once every two months for one year in 4 adult male jaguars (Panthera onca) housed at the São Paulo Zoo, SP, Brazil. Semen samples was collected by electroejaculation and analyzed for pH, total volume, motility (0-100%), status (0-5), total spermatozoa count and morphology. Blood samples was obtained by cephalic venipuncture immediately before the onset of electroejaculation and stored at -20ºC until assay of testosterone by RIA. Using a calliper, the length and width of each testis was measured and the values were combined to determine the testicular volume. Semen analyses demonstrated a high percentage of structurally abnormal sperm (mean = 51%) and low rates of motility...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Jaguars; Semen characters; Testosterone; Season.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-95961999000500008
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Comparison of serum hormone levels of captive and free-living maned wolves Chrysocyon brachyurus BJMBR
Maia,O.B.; Jácomo,A.T.A.; Bringel,B.A.; Kashivakura,C.K.; Oliveira,C.A.; Teodoro,L.O.F.; Silveira,L.; Teixeira da Costa,M.E.L.; Malta,M.C.C.; Furtado,M.M.; Torres,N.M.; Mattos,P.S.R.; Viau,.P; Lima,T.F.G.; Morato,R.G..
Serum hormone levels were compared between captive and free-living maned wolves and seasonal variations of sex hormones were studied. Blood samples were collected from 16 male and 26 female adult animals from Brazilian zoos, and from 30 male and 24 female free-living adults to determine serum progesterone and testosterone by radioimmunoassay. Serum testosterone concentrations varied (P < 0.05) across seasons for 16 captive males, being higher in autumn (2184.7 ± 355.1 pg/mL) than in summer (1080.7 ± 205.4 pg/mL), winter (1270.1 ± 276.6 pg/mL) and spring (963.9 ± 248.1 pg/mL), although they did not differ between summer, winter and spring. Testosterone concentration of 30 free-living males differed (P < 0.05) between autumn (824.1 ± 512.2 pg/mL),...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Maned wolf Chrysocyon brachyurus; Progesterone; Testosterone; Radioimmunoassay; Reproduction.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200015
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Effect of sildenafil (Viagra®) on the genital reflexes of paradoxical sleep-deprived male rats BJMBR
Andersen,M.L.; Bignotto,M.; Tufik,S..
Since there is evidence that paradoxical sleep deprivation (PSD) elicits penile erection (PE) and ejaculation (EJ), and that the erectile response of rats is mediated by nitric oxide, the present study sought to extend the latter finding by assessing the effects of sildenafil on the genital reflexes of male Wistar rats subjected to PSD. We also determined the influence of sildenafil on hormone concentrations. In the first experiment, sildenafil at doses ranging from 0.08 to 0.32 mg/kg was administered intraperitoneally to rats that had been deprived of sleep for 4 days and to home cage controls (N = 8-10/group). The frequency of PE and EJ was measured for 60 min. PSD alone induced PE in 50% of the animals; however, a single injection of sildenafil did not...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Paradoxical sleep deprivation; Sildenafil; Genital reflexes; Dopamine; Testosterone; Progesterone.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100008
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Morphological changes induced by testosterone in the mammary glands of female Wistar rats BJMBR
Chambô-Filho,A.; Camargos,A.F.; Pereira,F.E.L..
Increased levels of androgens in postmenopausal women are considered to be a risk factor for breast cancer. Testosterone, alone or in combination with estrogen, induces epithelial dysplasia and mammary tumors in Noble rats. Since this model of hormone-induced neoplasia has not been reported in other rat strains, we studied the effect of testosterone on the mammary gland morphology of female Wistar rats. Sixty adult, non-castrated, female Wistar rats were implanted in the dorsum midline with a silicone tube containing 50 mg testosterone (testosterone propionate in 30 animals and non-esterified testosterone in the remaining 30 animals) and 20 additional animals were implanted with empty tubes and used as control. Five animals per group were killed 30, 60,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Testosterone; Androgens; Mammary gland; Mammary gland hyperplasia; Mammary gland tumors.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000400008
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Sex differences in angiotensin II- induced hypertension BJMBR
Xue,B.; Johnson,A.K.; Hay,M..
Sex differences in the development of hypertension and cardiovascular disease have been described in humans and in animal models. In this paper we will review some of our studies which have as their emphasis the examination of the role of sex differences and sex steroids in modulating the central actions of angiotensin II (ANG II) via interactions with free radicals and nitric oxide, generating pathways within brain circumventricular organs and in central sympathomodulatory systems. Our studies indicate that low-dose infusions of ANG II result in hypertension in wild-type male mice but not in intact wild-type females. Furthermore, we have demonstrated that ANG II-induced hypertension in males is blocked by central infusions of the androgen receptor...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Angiotensin II; Estrogen; Estrogen a and ß receptors; Nitric oxide; Reactive oxygen species; Testosterone.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000500018
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Different stress modalities result in distinct steroid hormone responses by male rats BJMBR
Andersen,M.L.; Bignotto,M.; Machado,R.B.; Tufik,S..
Since both paradoxical sleep deprivation (PSD) and stress alter male reproductive function, the purpose of the present study was to examine the influence of PSD and other stressors (restraint, electrical footshock, cold and forced swimming, N = 10 per group) on steroid hormones in adult Wistar male rats. Rats were submitted to chronic stress for four days. The stressors (footshock, cold and forced swimming) were applied twice a day, for periods of 1 h at 9:00 and 16:00 h. Restrained animals were maintained in plastic cylinders for 22 h/day whereas PSD was continuous. Hormone determination was measured by chemiluminescent enzyme immunoassay (testosterone), competitive immunoassay (progesterone) and by radioimmunoassay (corticosterone, estradiol, estrone)....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Paradoxical sleep deprivation; Stress; Testosterone; Progesterone; Estrogen; Corticosterone.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000600003
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Behavioral cross-sensitization between testosterone and fenproporex in adolescent and adult rats BJMBR
Conceição,C.Q.; Engi,S.A.; Cruz,F.C.; Planeta,C.S..
The abuse of psychoactive drugs is considered a global health problem. During the last years, a relevant number of studies have investigated the relationship between anabolic-androgenic steroids (AAS) and other psychoactive drugs. AAS, such as testosterone, can cause a dependence syndrome that shares many features with the classical dependence to psychoactive substances. Pre-clinical evidence shows that there are interactions between testosterone and psychoactive drugs, such as cocaine. However, few studies have been performed to investigate the effect of repeated testosterone treatment on behavioral effects of amphetamine derivatives, such as fenproporex. The purpose of the present study was to investigate the effects of repeated testosterone...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Behavioral sensitization; Fenproporex; Testosterone; Rats.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000100603
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Plasma and testicular testosterone levels, volume density and number of Leydig cells and spermatogenic efficiency of rabbits BJMBR
Castro,A.C.S.; Berndtson,W.E.; Cardoso,F.M..
Plasma and tissue testosterone concentrations were determined by radioimmunoassay in 12 eight-month-old sexually mature New Zealand White rabbits and evaluated for possible associations with spermatogenic efficiency as well as with volume density and number of Leydig cells. Testicular tissue was processed histologically and histometry was performed in order to quantify germ cells, Sertoli cells and Leydig cells. Spermatogenic efficiency, reported as the ratios among germ cells (spermatogonia, primary spermatocytes and round spermatids) and by the ratio of germ cells to Sertoli cells, was not associated with testosterone levels. However, Leydig cell parameters such as number of Leydig cells per gram of testis, total number of Leydig cells per testis and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rabbit; Testosterone; Leydig cell; Spermatogenesis; Histometry.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000400014
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Changes in the hormone and lipid profile of obese adolescent Saudi females with acne vulgaris BJMBR
Abulnaja,K.O..
Acne vulgaris is a multifactorial disease affecting a majority of the adolescent population. The objective of this study was to test for a correlation between fasting serum lipid profiles and levels of testosterone, insulin, leptin, and interleukin 1-β (IL-1β) and the incidence of severe acne vulgaris in obese adolescent females. Four groups of adolescent females were studied: obese with acne, obese without acne, non-obese with acne, and non-obese without acne. Obese females with acne, compared to obese females without acne and non-obese subjects, had significantly higher serum triglycerides, low-density lipoprotein cholesterol and apolipoprotein-B (apo-B) (mean ± SD: 197 ± 13.7 vs 171 ± 11.5, 128 ± 8.3 vs 116 ± 7.7, 96 ± 13.7 vs 85 ± 10.3 mg/dL,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Acne vulgaris; Obesity; Testosterone; Adolescent females; Serum IL-1β.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600005
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Decreased spermatogenic and androgenic testicular functions in adult rats submitted to immobilization-induced stress from prepuberty BJMBR
Almeida,S.A.; Petenusci,S.O.; Anselmo-Franci,J.A.; Rosa-e-Silva,A.A.M.; Lamano-Carvalho,T.L..
We investigated whether chronic stress applied from prepuberty to full sexual maturity interferes with spermatogenic and androgenic testicular functions. Male Wistar rats (40 days old) were immobilized 6 h a day for 60 days. Following immobilization, plasma concentrations of corticosterone and prolactin increased 135% and 48%, respectively, while plasma luteinizing hormone and testosterone presented a significant decrease of 29% and 37%, respectively. Plasma concentration of follicle-stimulating hormone was not altered in stressed rats. Chronic stress reduced the amount of mature spermatids in the testis by 16% and the spermatozoon concentration in the cauda epididymidis by 32%. A 17% reduction in weight and a 42% decrease in DNA content were observed in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Immobilization; Spermatogenesis; LH; FSH; Testosterone; Prolactin.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001100013
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