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	Provedor de dados BJMBR (2) Autor Chen,Xiao (1) Gao,Ying-fang (1) Nagelkerken,L. (1) Zhang,Guo-hua (1) Zhang,Xue-ling (1) Palavra-chave Th1 cells (2) Antigen-presenting cells (1) Artesunate (1) CD4+ T cells (1) Cytokines (1) Experimental allergic encephalomyelitis (1) Glucocorticoids (1) MiR-142 (1) Multiple sclerosis (1) Ovarian cancer (1) Sirt1 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 1998 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Role of Th1 and Th2 cells in autoimmune demyelinating disease BJMBR Nagelkerken,L.. Evidence is accumulating that Th1 cells play an important role in the development of multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE), whereas Th2 cells contribute to recovery from disease. A major determinant in the development of Th1 and Th2 cells is the type of antigen-presenting cell (APC) involved and its functional characteristics, e.g., the production of interleukin-12. Therefore, modulation of APC might interfere with the development of Th1 type responses and as such be beneficial for MS and EAE. The potential of cytokines, in particular interleukin-10, and glucocorticoids to exert a selective effect on APC, and as a consequence to affect the Th1-Th2 balance in EAE, is discussed Tipo: Info:eu-repo/semantics/article Palavras-chave: Multiple sclerosis; Experimental allergic encephalomyelitis; Cytokines; Glucocorticoids; Th1 cells; Antigen-presenting cells. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100007 Artesunate promotes Th1 differentiation from CD4+ T cells to enhance cell apoptosis in ovarian cancer via miR-142 BJMBR Chen,Xiao; Zhang,Xue-ling; Zhang,Guo-hua; Gao,Ying-fang. The aim of this study was to evaluate the influence of artesunate on Th1 differentiation and its anti-tumor effect on ovarian cancer. A Murine ovarian cancer model was established by ID8 cells transplantation. The expression of miR-142 and Sirt1 proteins in peripheral CD4+ T cells were quantified with qRT-PCR and western blot, respectively. Peripheral CD4+ T cells were induced for Th1 differentiation. The percentages of apoptosis of Th1/CD4+ T cells and ovarian cancer cells were analyzed by flow cytometry. The IFN-γ level was examined through enzyme-linked immunosorbent assay. Artesunate promoted miR-142 expression in peripheral CD4+ T cells and Th1 differentiation from CD4+ T cells. Artesunate promoted cell apoptosis of ovarian cancer cells by inducing... Tipo: Info:eu-repo/semantics/article Palavras-chave: Artesunate; Ovarian cancer; CD4+ T cells; Th1 cells; MiR-142; Sirt1. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000500606 Registros recuperados: 2 Primeira ... 1 ... Última

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