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	Provedor de dados BJMBR (2) Autor Carvalho,E.M. (1) Rocha,P.N. (1) Palavra-chave Thromboxane (2) Corticosteroids (1) Endothelin-1 (1) Inflammation (1) Mast cell (1) Platelet aggregating factor (1) Prostaglandin D (1) Prostaglandins (1) Rejection (1) Synaptic plasticity (1) Transplantation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2005 (1) 1997 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Prostanoids modulate inflammation and alloimmune responses during graft rejection BJMBR Rocha,P.N.; Carvalho,E.M.. Acute rejection of a transplanted organ is characterized by intense inflammation within the graft. Yet, for many years transplant researchers have overlooked the role of classic mediators of inflammation such as prostaglandins and thromboxane (prostanoids) in alloimmune responses. It has been demonstrated that local production of prostanoids within the allograft is increased during an episode of acute rejection and that these molecules are able to interfere with graft function by modulating vascular tone, capillary permeability, and platelet aggregation. Experimental data also suggest that prostanoids may participate in alloimmune responses by directly modulating T lymphocyte and antigen-presenting cell function. In the present paper, we provide a brief... Tipo: Info:eu-repo/semantics/article Palavras-chave: Thromboxane; Prostaglandins; Transplantation; Inflammation; Rejection; Corticosteroids. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001200004 Role of mast cell- and non-mast cell-derived inflammatory mediators in immunologic induction of synaptic plasticity BJMBR We have previously discovered a long-lasting enhancement of synaptic transmission in mammal autonomic ganglia caused by immunological activation of ganglionic mast cells. Subsequent to mast cell activation, lipid and peptide mediators are released which may modulate synaptic function. In this study we determined whether some mast cell-derived mediators, prostaglandin D2 (PGD2; 1.0 µM), platelet aggregating factor (PAF; 0.3 µM) and U44619 (a thromboxane analogue; 1.0 µM), and also endothelin-1 (ET-1; 0.5 µM) induce synaptic potentiation in the guinea pig superior cervical ganglion (SCG), and compared their effects on synaptic transmission with those induced by a sensitizing antigen, ovalbumin (OVA; 10 µg/ml). The experiments were carried out on SCGs... Palavras-chave: Prostaglandin D; Platelet aggregating factor; Endothelin-1; Thromboxane; Mast cell; Synaptic plasticity. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000700014 Registros recuperados: 2 Primeira ... 1 ... Última

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