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| Registros recuperados: 21 | |
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| Bouilly, Karine; Leitao, Alexandra; Mccombie, Helen; Chaves, R.; Guedes Pinto, H; Boudry, Pierre; Lapegue, Sylvie. |
| In the Pacific oyster, Crassostrea gigas hypodiploid aneuploid cells with 2n=19, 18 or 17 chromosomes have regularly been reported. There is a negative correlation between somatic aneuploidy and growth rate in oysters (Leitão et al., 2001a) as well as evidence for a genetic basis (Leitão et al., 2001b). Furthermore, non-random chromosome loss has been demonstrated in aneuploid karyotypes of C. gigas using the G-banding technique (Leitão et al., 2001c). This poster summarises different studies used to investigate the effects of the herbicide atrazine on the level of aneuploidy in this species |
| Tipo: Text |
Palavras-chave: Genetic; Aneuploidy; Toxicology; Impact; Atrazine; Crassostrea gigas; Pacific oysters. |
| Ano: 2004 |
URL: http://archimer.ifremer.fr/doc/2004/acte-3489.pdf |
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| Brusle, Jacques. |
| Many algal blooms ("red tides" or "brown tides") may be noxious for finfish, either causing anoxia through decay process, clogging the gills or producing specific toxins. Since the 1970's, records of the incidence of injury and mortality to wild and cultured fish due to toxic phytoplankton have increased. It was even demonstrated that toxic algal blooms are spreading in intensity, geographic distribution and number of algal species involved. Thus, algal blooms are becoming one of the major economic threat to fisheries and fish culture industry. This review deals with the literature available (more than 250 references) on the occurrence of fish kills associated with worldwide algal blooms. Their negative effects on fish that result in economic losses are... |
| Tipo: Text |
Palavras-chave: Harmful algal bloom; Finfish; Toxicology; Pathology; Mortality. |
| Ano: 1994 |
URL: http://archimer.ifremer.fr/doc/1994/rapport-1431.pdf |
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| Pascale Quintino,Marisa; Simões,Manuel de Jesus; Uchiyama Nakamura,Mary; Martins Oliveira-Filho,Ricardo; Espiridião,Silvia; Kulay Júnior,Luiz. |
| Although being used for years in the treatment of tuberculosis, no data are available in the literature on the safety of pyrazinamide during pregnancy. Accordingly, we aimed to make a first approach to this problem by evaluating the effects of this drug administered during the entire pregnancy of albino rats. Fourty female, EPM-1 Wistar albino rats of about 250 g b.w. were used. Upon conception (day zero of pregnancy) the animals were randomly divided in 4 groups of 10 rats each and labeled as follows. Controls (C), animals treated with the drug vehicle (destilled water); experimental groups (E1, E2 and E3), animals treated with 35, 105 or 315 mg/kg b.w. pyrazinamide by gavage (oral route) once daily up to the term (20th day of pregnancy). Drug or vehicle... |
| Tipo: Journal article |
Palavras-chave: Pyrazinamide; Toxicology; Rat; Pregnancy. |
| Ano: 2003 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000400007 |
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| Rodero,Ademir Barianni; Rodero,Lucas de Souza; Azoubel,Reinaldo. |
| Sucralose is a non-nutritive artificial sweetener, 600 times sweeter than sucrose, and is very stable at high temperatures, among other characteristics. It was approved by the FDA, in 1999, to be utilized in foods, beverages, pharmaceutical products, diets and vitamin supplements. Studies suggest a diffusion, through the placental barrier, of small doses of sucralose and its metabolites. Its hydrolysis products (4-CG e 1,6-DCF) are more rapidly absorbed than sucralose: 4-CG is excreted intact in the urine, and 1,6-DCF undergoes reduction with elimination by the urine or rapid conjugation with glutathione. Various organs can be affected by ingestión of high doses of sucralose. As a result of the rise in global consumption of sweeteners and light- or... |
| Tipo: Journal article |
Palavras-chave: Sucralose; Sweetener; Toxicology. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100040 |
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| Almansour,Mansour; Jarrar,Qais; Battah,Abdelkader; Jarrar,Bashir. |
| Silver nanoprticles (SNPs) are invested in medical, industrial and environmental applications. Little if any, is known about the morphometric alterations induced by the toxicity of SNPs. The aim of the present work is to find out the effect of variable size of SNPs on different morphometric parameters. Adult healthy male mice (BAL/C) were subjected to (10 nm, 20 nm, 40 nm 60 nm and 100 nm) SNPs for 35 days. Silver NPs caused non-significant decline on the average weight, significant decline in food consumption, increase in water intake, unilateral blindness, tanning fur color and cholestasis together with a decrease in the relative ratio of the liver, kidney and spleen weight to body weight. Mice subjected to 10 nm and 20 nm were more affected than mice... |
| Tipo: Journal article |
Palavras-chave: Silver nanoparticles; Morphology; Toxicology; Liver; Kidney; Spleen. |
| Ano: 2015 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200022 |
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| Hoeksema, B.; Crowther, A.L.. |
| Phyllodiscus semoni is a morphologically variable sea anemone species from the Indo-Pacific with morphotypes ranging from upright and branched to low-lying and rounded. The apparent camouflage strategies of this sea anemone allow it to resemble other species or objects in its environment, such as stony corals, soft corals, seaweeds, or rocky boulders covered by algae, which may help it to avoid recognition by potential predators. Occasionally, it occurs in aggregations that may result from asexual reproduction. A high level of intraspecific morphological variation, including co-occurring aggregations of three different morphotypes, was observed in the Spermonde Archipelago off Makassar, South Sulawesi, Indonesia. The co-occurrence of aggregations with... |
| Tipo: Article / Letter to the editor |
Palavras-chave: Actiniaria; Aliciidae; Camouflage; Indonesia; Morphotype; Southern Japan; Toxicology; 42.72. |
| Ano: 2011 |
URL: http://www.repository.naturalis.nl/record/402023 |
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| Andretta,Ines; Kipper,Marcos; Hauschild,Luciano; Lehnen,Cheila Roberta; Remus,Aline; Melchior,Raquel. |
| ABSTRACT Little is known about the toxicity of concomitantly occurring mycotoxins in pig diets. This study was conducted to evaluate, through meta-analysis, the individual and the combined effects of mycotoxins on pig performance. The meta-analysis followed three sequential analyses (graphical, correlation, and variance-covariance) based on a database composed of 85 published papers, 1,012 treatments and 13,196 animals. Contamination of diets with individual mycotoxins reduced (p < 0.05) feed intake by 14 % and weight gain by 17 %, while combined mycotoxins reduced the same responses by 42 % and 45 %, respectively, in comparison with the non-challenged group. The correlation (p < 0.05) between reduction in weight gain (ΔG) and reduction in feed... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Modelling; Sanitary challenge; Swine; Toxicology. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-90162016000400328 |
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| Mello, Giovanni Lemos de; EPAGRI; Amaral Júnior, Hilton; Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina - Epagri; Garcia, Silvano; Empresa de Pesquisa Agropecuária e Extensão Rural de Santa Catarina - Epagri; Vinatea, Luis; UFSC. |
| The objective of this study was to determine the LC50 (96h) of two pesticides: Sirius® 250 SC herbicide of the pyrazosulfuron-ethyl group, and Talcord® insecticide of the permethrin group, on juvenile Litopenaeus vannamei. Shrimp total hemocyte count (THC) was also determined as an indication of physiological alterations caused by the pesticides. Juvenile shrimp (5.0 ± 0.5 g) were exposed to the following concentrations: 0, 0.1, 1.0, 10, 100 and 1000 µg L-1 Sirius® 250 SC; and 0, 0.001, 0.01, 0.1, 1.0 and 10 µg L-1 Talcord®. The Talcord® LC50 (96h) was of 0.00933 µg L-1 or 9.33 ng L-1. There were no significant changes in the THC between control and test groups. No... |
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Palavras-chave: Toxicology; Pesticides; Shrimp culture; Litopenaeus vannamei Toxicology; Pesticides; Shrimp culture; Litopenaeus vannamei. |
| Ano: 2011 |
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/6974 |
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| BARBOSA,HUMBERTO M.; NASCIMENTO,JAILSON N. DO; ARAÚJO,THIAGO A.S.; DUARTE,FILIPE S.; ALBUQUERQUE,ULYSSES P.; VIEIRA,JEYMESSON R.C.; SANTANA,EDSON R.B. DE; YARA,RICARDO; LIMA,CLÁUDIA S.A.; GOMES,DAYANE A.; LIRA,EDUARDO C.. |
| ABSTRACT Spondias tuberosa Arruda, popularly named as umbu, is native from savanna-like vegetation and widely used for medicinal purposes, however, the toxicological profile is not available yet. This study evaluated the phytochemical profile and acute toxicity and citoxicity of Ethanolic Extract of Spondias tuberosa Arruda Bark (EEStb) in hematological, biochemical and histopathological parameters. Female Wistar rats were divided into: control (C) and animal treated single doses of 300mg/Kg (EEStb300) or 2.000mg/kg body weight (ESStb2.000) of the EEStb. After 24 hours and 14 days from gavage, the behavior, hematological, biochemical and histopathological parameters were assayed. Cytotoxicity effect was evaluated on HEp-2 cell lines. Neither EEStb300 nor... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acute toxicity; Cytotoxicity; Phytomedicine; Safety; Spondias tuberosa Arruda; Toxicology. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501993 |
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| Santos,W.G.; Silveira,T.L.; Fiúza,A.T.L.; Botelho,A.F.M.; Gonçalves,I.N.N.; Ferreira,E.; Soto-Blanco,B.; Melo,M.M.. |
| RESUMO Este estudo objetiva reportar a ocorrência de apoptose in vivo induzida pelo veneno da serpente Bothrops alternatus em células musculares esqueléticas. Cinco coelhos machos, adultos, receberam 150μg/kg de veneno no músculo vasto lateral, enquanto outros cinco animais receberam 0,1% de BSA diluído em PBS no mesmo local. Após 12 horas, os animais foram eutanasiados, e amostras do local de inoculação foram coletadas para análise histopatológica. Foram evidenciadas necrose e hemorragia nas células musculares. Além disso, a análise imuno-histoquímica para identificação de caspase-3 ativada revelou marcações granulares e agregadas no citoplasma das células musculares, compatíveis com o processo de apoptose. Este é o primeiro relato que confirma o veneno... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Snake venom; Botropic venom; Apoptosis; Toxicology; Rabbit. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000100349 |
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| Talbot,Prue; Lin,Sabrina. |
| Numerous studies have repeatedly shown that women who smoke experience problems establishing and maintaining pregnancies, and recent work has further demonstrated that the in utero effects of smoke may not be manifested until months or even years after birth. The purpose of this review is to examine the recent literature dealing with the effects of cigarette smoke on the earliest stages of human prenatal development. Studies in this area have included the use of animal models, patients undergoing in vitro fertilization, and embryonic stem cell models. Events leading to fertilization, such as cumulus expansion, hyperactivation of sperm motility, and oocyte pick-up by the oviduct are all impaired by smoke exposure in animal models. Steps crucial to... |
| Tipo: Journal article |
Palavras-chave: Cigarette smoke; Embryos; Fertilization; IVF; Stem cells; Toxicology. |
| Ano: 2011 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000200011 |
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| Pittol,Michele; Tomacheski,Daiane; Simões,Douglas Naue; Ribeiro,Vanda Ferreira; Santana,Ruth Marlene Campomanes. |
| ABSTRACT The increasing concern over the spread of diseases has lead to a high consumption of antimicrobial additives in the medical and industrial fields. Since these particles can lixiviate from loaded materials, the contact between this additive and mammalian cells can occur during manufacture, use and disposal of the products. Silver on fumed silica (AgNP_SiO2) and titanium dioxide (TiO2) can be used as antimicrobial additives that are applied in polymeric formulation. While these additives can inhibit bacteria, fungus and virus proliferation; they may also be harmful to humans. Standard toxicological studies were undertaken using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide), CBPI (cytokinesis-block proliferation index) and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Titanium dioxide; Silver; Silica; Toxicology; Mammalian cell. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100318 |
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| Andrade,E.L.; Bento,A.F.; Cavalli,J.; Oliveira,S.K.; Schwanke,R.C.; Siqueira,J.M.; Freitas,C.S.; Marcon,R.; Calixto,J.B.. |
| The process of drug development involves non-clinical and clinical studies. Non-clinical studies are conducted using different protocols including animal studies, which mostly follow the Good Laboratory Practice (GLP) regulations. During the early pre-clinical development process, also known as Go/No-Go decision, a drug candidate needs to pass through several steps, such as determination of drug availability (studies on pharmacokinetics), absorption, distribution, metabolism and elimination (ADME) and preliminary studies that aim to investigate the candidate safety including genotoxicity, mutagenicity, safety pharmacology and general toxicology. These preliminary studies generally do not need to comply with GLP regulations. These studies aim at... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Non-clinical studies; GLP studies; Safety; Pharmacokinetics; Toxicology. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001200301 |
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| Registros recuperados: 21 | |
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