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	Provedor de dados Anais da ABC (AABC) (1) BJMBR (1) Autor BRANDÃO,ADEILTON (1) Barbosa,C.F. (1) Chung,M.C. (1) Cicarelli,R.M.B. (1) Ferreira,E.I. (1) Okuda,E.S. (1) SAMUDIO,FRANKLYN (1) Mais... Palavra-chave Trans-splicing (2) Calmodulin (1) Epimastigote (1) Hydroxymethylnitrofurazone (1) Minimum free energy (1) Permeable cells (1) RNA processing (1) RNA secondary structure (1) Trypanocidal drugs (1) Trypanosoma cruzi (1) Untranslated region (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2007 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Minimum free energy predicted base pairing in the 39 nt spliced leader and 5’ UTR of calmodulin mRNA from Trypanosoma cruzi: influence of the multiple trans-splicing sites Anais da ABC (AABC) SAMUDIO,FRANKLYN; BRANDÃO,ADEILTON. ABSTRACT We analyzed the compositional changes and the stable base pairs in the predicted secondary structure of the 5’ UTR calmodulin mRNA in T. cruzi. The three copies of calmodulin in T. cruzi genome display variable position of the trans splicing sites and give rise to several mRNA that differs slightly on 5’ UTR composition in the epimastigote stage. We show that the pattern of high probability base pairs in the minimum free energy predicted secondary structures of the calmodulin 5’ UTR remains unchanged despite the nucleotide composition variation. However, the 39 nt spliced leader (mini-exon, the 5’ exon sequence transferred to trypanosome mRNAs by the mechanism of trans splicing) shows a variable pattern of high and low probability base pairing as... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trans-splicing; Untranslated region; Calmodulin; Epimastigote; RNA secondary structure; Minimum free energy. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000502311 Rapid test for the evaluation of the activity of the prodrug hydroxymethylnitrofurazone in the processing of Trypanosoma cruzi messenger RNAs BJMBR Barbosa,C.F.; Okuda,E.S.; Chung,M.C.; Ferreira,E.I.; Cicarelli,R.M.B.. No fully effective treatment has been developed since the discovery of Chagas' disease by Carlos Chagas in 1909. Since drug-resistant Trypanosoma cruzi strains are occurring and the current therapy is effectiveness in the acute phase but with various adverse side effects, more studies are needed to characterize the susceptibility of T. cruzi to new drugs. Many natural and/or synthetic substances showing trypanocidal activity have been used, even though they are not likely to be turned into clinically approved drugs. Originally, drug screening was performed using natural products, with only limited knowledge of the molecular mechanism involved in the development of diseases. Trans-splicing, which is unusual RNA processing reaction and occurs in nematodes... Tipo: Info:eu-repo/semantics/article Palavras-chave: Trypanosoma cruzi; Trans-splicing; Trypanocidal drugs; Permeable cells; RNA processing; Hydroxymethylnitrofurazone. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000100005 Registros recuperados: 2 Primeira ... 1 ... Última

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