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	Provedor de dados BJMBR (2) Biol. Res. (1) Autor Court,Felipe A (1) Fu,Z.X. (1) Jia,Y.J. (1) Jia,Y.L. (1) Kerkis,A.Y. (1) Kerkis,I.E. (1) Mello,M.R.B. (1) Pereira,L.V. (1) Sukoyan,M.A. (1) Visintin,J.A. (1) Zhang,B.H. (1) Álvarez,Jaime (1) Mais... Palavra-chave Transgenic mouse (3) Amyloid precursor protein (1) Dementia (1) Down syndrome cell adhesion molecule (1) Glia (1) Hippocampus (1) Human genetic diseases (1) Maintenance of axons (1) Mouse model (1) Murine embryonic stem cells (1) Protein synthesis (1) Radioactive wave (1) Schwann cell (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Journal article (1) Ano 2017 (1) 2011 (1) 2002 (1) País Brazil (2) Chile (1) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Slow axoplasmic transport under scrutiny Biol. Res. Court,Felipe A; Álvarez,Jaime. The origin of axoplasmic proteins is central for the biology of axons. For over fifty years axons have been considered unable to synthesize proteins and that cell bodies supply them with proteins by a slow transport mechanism. To allow for prolonged transport times, proteins were assumed to be stable, i.e., not degraded in axons. These are now textbook notions that configure the slow transport model (STM). The aim of this article is to cast doubts on the validity of STM, as a step toward gaining more understanding about the supply of axoplasmic proteins. First, the stability of axonal proteins claimed by STM has been disproved by experimental evidence. Moreover, the evidence for protein synthesis in axons indicates that the repertoire is extensive and the... Tipo: Journal article Palavras-chave: Protein synthesis; Radioactive wave; Maintenance of axons; Schwann cell; Glia; Transgenic mouse. Ano: 2011 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000400001 Hippocampal overexpression of Down syndrome cell adhesion molecule in amyloid precursor protein transgenic mice BJMBR Jia,Y.L.; Fu,Z.X.; Zhang,B.H.; Jia,Y.J.. Down syndrome cell adhesion molecule (DSCAM) is located within the Down syndrome critical region of chromosome 21. DSCAM is a broadly expressed neurodevelopmental protein involved in synaptogenesis, neurite outgrowth, and axon guidance. We previously demonstrated DSCAM overexpression in the cortex of amyloid precursor protein (APP) transgenic mice, suggesting possible regulatory interactions between APP and DSCAM. APP mice exhibit deficits in hippocampus-dependent learning and memory. In this preliminary study, we examined age-related changes in DSCAM expression within the hippocampus in 16 APP transgenic mice (1, 3, 6 and 12 months old). Hippocampus-dependent spatial memory was assessed in APP mice and age-matched wild type littermates (WTs) using the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Down syndrome cell adhesion molecule; Amyloid precursor protein; Transgenic mouse; Hippocampus; Dementia. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600603 Establishment of new murine embryonic stem cell lines for the generation of mouse models of human genetic diseases BJMBR Sukoyan,M.A.; Kerkis,A.Y.; Mello,M.R.B.; Kerkis,I.E.; Visintin,J.A.; Pereira,L.V.. Embryonic stem cells are totipotent cells derived from the inner cell mass of blastocysts. Recently, the development of appropriate culture conditions for the differentiation of these cells into specific cell types has permitted their use as potential therapeutic agents for several diseases. In addition, manipulation of their genome in vitro allows the creation of animal models of human genetic diseases and for the study of gene function in vivo. We report the establishment of new lines of murine embryonic stem cells from preimplantation stage embryos of 129/Sv mice. Most of these cells had a normal karyotype and an XY sex chromosome composition. The pluripotent properties of the cell lines obtained were analyzed on the basis of their alkaline phosphatase... Tipo: Info:eu-repo/semantics/article Palavras-chave: Human genetic diseases; Murine embryonic stem cells; Mouse model; Transgenic mouse. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000500004 Registros recuperados: 3 Primeira ... 1 ... Última

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