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	Provedor de dados BJPS (1) J. Venom. Anim. Toxins incl. Trop. Dis. (1) Autor Avadi,MR (1) Eskandari,R (1) Mir Mohammad Sadeghi,A (1) Mohammadpour Dounighi,N (1) Rezayat,M (1) Tilkan,Müşerref Günseli Yüksel (1) Zolfagharian,H (1) Özdemir,Nurten (1) Mais... Palavra-chave Chitosan (2) Tripolyphosphate (2) Antigen delivery system (1) Flurbiprofen (1) Ionotropic gelation (1) Mesobuthus eupeus (1) Microsphere (1) Nanoparticle (1) Venom (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2017 (1) 2012 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Preparation and in vitro characterization of chitosan nanoparticles containing Mesobuthus eupeus scorpion venom as an antigen delivery system J. Venom. Anim. Toxins incl. Trop. Dis. Mohammadpour Dounighi,N; Eskandari,R; Avadi,MR; Zolfagharian,H; Mir Mohammad Sadeghi,A; Rezayat,M. Hydrophilic nanoparticles have been widely investigated in recent years as delivery systems for therapeutic macromolecules such as antigens. In the present study Mesobuthus eupeus venom-loaded chitosan nanoparticles were prepared via ionic gelation of tripolyphosphate (TPP) and chitosan. The optimum encapsulation efficiency (91.1%) and loading capacity (76.3%) were obtained by a chitosan concentration of 2 mg/mL, chitosan-to-TPP mass ratio of 2 and M. eupeus venom concentration of 500 µg/mL. The average nanoparticle size at optimum conditions was determined by Zetasizer (Malvern Instruments, UK). The nanoparticle size was about 370 nm (polydispersity index: 0.429) while the zeta potential was positive. Transmission electron microscope (TEM) imaging showed... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nanoparticle; Chitosan; Tripolyphosphate; Venom; Antigen delivery system; Mesobuthus eupeus. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100006 Investigation of the parameters affecting the release of flurbiprofen from chitosan microspheres BJPS Tilkan,Müşerref Günseli Yüksel; Özdemir,Nurten. ABSTRACT Flurbiprofen (FLB), a NSAID, widely used for preventing pain generally for arthritis or dental problems. In this study, FLB loaded chitosan microspheres were prepared by ionotropic gelation method. In this method, microspheres were formed by dropping chitosan solutions containing FLB into sodium alginate solutions including sodium tripolyphosphate (TPP). A variety of formulation parameters like drug:polymer ratio, drug concentration, polymer’s molecular weight, polymer concentration, pH and the concentration of TPP solutions, drying method and stirring time were analyzed. The dissolution studies were performed in a shaking water bath in pH 7.4 phosphate buffer saline (PBS) at 37 °C. Laser diffractometer was used for particle size analysis, and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Flurbiprofen; Chitosan; Tripolyphosphate; Ionotropic gelation; Microsphere. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400621 Registros recuperados: 2 Primeira ... 1 ... Última

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