|
|
|
|
|
| Evangelista, Adriane Feijó; Kavati, Erica Akemi; Jankevicius, José Vitor; Menolli, Rafael Andrade. |
| Glycoalkaloids are important secondary metabolites accumulated by plants as protection against pathogens. One of them, α-tomatine, is found in high concentrations in green tomato fruits, while in the ripe fruits, its aglycone form, tomatidine, does not present a protective effect, and it is usual to find parasites of tomatoes like Phytomonas serpens in these ripe fruits. To investigate the sensitivity of trypanosomatids to the action of α-tomatine, we used logarithmic growth phase culture of 20 trypanosomatids from insects and plants and Trypanosoma cruzi. The lethal dose 50% (LD50) was determined by mixing 107 cells of the different isolates with α-tomatine at concentrations ranging from 10-3 to 10-8 M for 30 min at room temperature. The same tests... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 2.13.01.00-0 tomato alkaloids; Trypanocidal activity; Phytomonas; Leptomonas; Crithidia; Herpetomonas. Protozoologia. |
| Ano: 2018 |
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/41853 |
| |
|
|
| SAÚDE-GUIMARÃES,DÊNIA A.; RASLAN,DÉLIO S.; CHIARI,EGLER; OLIVEIRA,ALAÍDE B. DE. |
| Chemical transformations of eremantholide C (1), a sesquiterpene lactone that was isolated from Lychnophora trichocarpha Spreng. led to five new derivatives: 1′,2′- epoxyeremantholide C (2), 5-n-propylamine-4,5-dihydro-1′,2′-epoxyeremantholide C (3), 5-n-propylammonium-4,5-dihydro-1′,2′-epoxyeremantholide C chloride (4), 5-n-propylammonium-4,5-dihydroeremantolide C chloride (5) and 16-O-ethyleremantholide C (6). The structures of all these derivatives were assigned on the basis of IR, MS, 1H and 13C NMR data by 1D and 2D techniques. Eremantholide C and the derivatives 2, 4 and 5 were evaluated against trypomastigotes Y and CL strains of Trypanosoma cruzi. Eremantholide C completely inhibited the growth of both the parasites strains while all derivatives... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Eremantholide C derivatives; Lychnophora trichocarpha; NMR; Sesquiterpene lactones; Trypanocidal activity. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000401563 |
| |
|
|
| Rosas,L.V.; Cordeiro,M.S.C.; Campos,F.R.; Nascimento,S.K.R.; Januário,A.H.; França,S.C.; Nomizo,A.; Toldo,M.P.A.; Albuquerque,S.; Pereira,P.S.. |
| Ampelozizyphus amazonicus Ducke is a tree commonly found in the Amazon region and an extract of its stem bark is popularly used as an antimalarial and anti-inflammatory agent and as an antidote to snake venom. Ursolic acid; five lupane type triterpenes: betulin, betulinic acid, lupenone, 3ß-hydroxylup-20(29)-ene-27,28-dioic acid, and 2a,3ß-dihydroxylup-20(29)-ene-27,28-dioic acid, and three phytosteroids: stigmasterol, sitosterol and campesterol, have been isolated from stem extracts of A. amazonicus Ducke. Their structures were characterized by spectral data including COSY and HMQC. In an in vitro biological screening of the isolated compounds, 3ß-hydroxylup-20(29)-ene-27,28-dioic acid was cytotoxic against the SKBR-3 human adenocarcinoma cell line (1 to... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ampelozizyphus amazonicus; Rhamnaceae; Pentacyclic triterpenes; Cytotoxic activity; Trypanocidal activity. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000500009 |
| |
|
|
|
