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	Provedor de dados BJMBR (1) Autor Henrique-Silva,F. (1) Silveira,H.C.S. (1) Soares-Costa,A. (1) Sommer,C.A. (1) Palavra-chave Calcineurin (1) Down's syndrome (1) Down's syndrome candidate region 1 (1) Protein interactions (1) Two-hybrid system (1) Ubiquitously expressed transcript (1) Mais... Tipo do documento Info:eu-repo/semantics/other (1) Ano 2004 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última A calcineurin inhibitory protein overexpressed in Down's syndrome interacts with the product of a ubiquitously expressed transcript BJMBR Silveira,H.C.S.; Sommer,C.A.; Soares-Costa,A.; Henrique-Silva,F.. The Down's syndrome candidate region 1 (DSCR1) protein, encoded by a gene located in the human chromosome 21, interacts with calcineurin and is overexpressed in Down's syndrome patients. As an approach to clarifying a putative function for this protein, in the present study we used the yeast two-hybrid system to identify DSCR1 partners. The two-hybrid system is a method that allows the identification of protein-protein interactions through reconstitution of the activity of the yeast GAL 4 transcriptional activator. The gene DSCR1 fused to the GAL 4 binding domain (BD) was used to screen a human fetal brain cDNA library cloned in fusion with the GAL 4 activation domain (AD). Three positive clones were found and sequence analysis revealed that all the... Tipo: Info:eu-repo/semantics/other Palavras-chave: Down's syndrome; Down's syndrome candidate region 1; Calcineurin; Two-hybrid system; Ubiquitously expressed transcript; Protein interactions. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000600002 Registros recuperados: 1 Primeira ... 1 ... Última

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