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| CIRINO,LORENA M.D.; VERGNE,DAVIANE M.C.; SANTANA,PATRÍCIA F.; ALMEIDA,ENRIK DE; COSTA,LUIZ P. DA; ALBUQUERQUE-JÚNIOR,RICARDO L.C. DE; LIMA-VERDE,ISABEL B.; PADILHA,FRANCINE F.; CARDOSO,JULIANA C.. |
| ABSTRACT The objective of this work was to study the reduction in the capsaicin toxicity by encapsulation in liposomes. Capsaicin was extracted from peppers and characterized with high performance liquid chromatography (HPLC). We determined the zeta potential, polydispersivity index (PdI) and vesicle size of liposomes. Wistar rats were submitted to intravesical instillation of liposomes (LIP), capsaicin (CAP) or liposomes with capsaicin (CAPLIP). After 24 hours, bladders were removed for histological analysis. Vesicle size ranged from 68 to 105 nm with PdI smaller than 0.2 and zeta potential around -30 mV. The vesicles maintained stability over the 14-day study. The histological analysis of the CAP group showed intense inflammation in almost all bladder... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Capsaicin; Liposomes; Urinary incontinence; Intravesical administration. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401539 |
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| Gascón,Maria Rita Polo; Mellão,Mirella de Almeida; Mello,Sandra Helena; Negrão,Rosangela Maria; Casseb,Jorge; Oliveira,Augusto César Penalva de. |
| ABSTRACT This study evaluated the impact of urinary incontinence (UI) on sexuality, body image, mood, and quality of life of patients with myyelopathy associated with HTLV-1/tropical spastic paraparesis (HAM/TSP). The sample consisted of 31 HAM/TSP outpatients, of both sexes, followed-up at the Emílio Ribas Infectology Institute. The following instruments were used: sociodemographic questionnaire, Hospital Anxiety and Depression Scale (HAD), Body Image Assessment Scale, Sexual Quotient Female (QS-F) and Male (QS-M) Versions, King's Health Questionnaire (KHQ), and Revised OSAME Motor Disability Score. Data analysis was performed using descriptive statistics and the Mann-Whitney U-test was used for group comparison. The presence of UI was reported by 13... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HAM/TSP; Quality of life; Urinary incontinence. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000400288 |
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| Schwanke,C.H.A.; Bittencourt,L.; Noronha,J.A.P.; Augustin,S.A.J.; Jung,I.E.; Cruz,I.B.M.. |
| The regulation of bladder function is influenced by central serotonergic modulation. Several genetic polymorphisms related to serotonin control have been described in the literature. T102C polymorphism of the serotonin receptor 2A gene (5-HT2A) has been shown to be associated with certain diseases such as non-fatal acute myocardial infarction, essential hypertension, and alcoholism. In the present study, we examined the association between 5-HT2A gene polymorphism and urinary incontinence in the elderly. A case-control study was performed in 298 elderly community dwellers enrolled in the Gravataí-GENESIS Project, Brazil, which studies gene-environmental interactions in aging and age-related diseases. Clinical, physical, biochemical, and molecular analyses... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: T102C polymorphism of the serotonin receptor 2A gene; 5-HT2A gene polymorphism; Urinary incontinence; Elderly patients. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001000003 |
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