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| Chen,Yuhang; Zhu,Zaibiao; Guo,Qiaosheng; Zhang,Lixia; Zhang,Xiaoming. |
| Prunella vulgaris L. (Labiatae) contains a variety of structurally diverse natural products, primarily rosmarinic acid (RA), ursolic acid (UA) and oleanolic acid (OA), which possess a wide array of biological properties. In the present study, P. vulgaris was harvested at three developmental stages (vegetative, full-flowering and mature-fruiting stages), dissected into stem and leaf tissues and assayed for chemical contents using high performance liquid chromatography. Significant changes in the concentrations of the major secondary metabolites (RA, UA and OA) were observed at the different development stages. The highest concentrations of RA, UA and OA were found at the full-flowering stage (15.83 mg/g dry weight (DW) RA, 1.77 mg/g DW UA and 0.65 mg/g DW... |
| Tipo: Journal article |
Palavras-chave: Prunella vulgaris L.; Ontogenetic and morphogenetic variation; Rosmarinic acid; Ursolic acid; Oleanolic acid. |
| Ano: 2012 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000200009 |
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| Santos,Fernanda M. dos; Souza,Maria Gorete de; Crotti,Antônio E. Miller; Martins,Carlos H. G.; Ambrósio,Sérgio R.; Veneziani,Rodrigo C. S.; Silva,Márcio L. Andrade e; Cunha,Wilson R.. |
| This work describes the phytochemical study of the extracts from aerial parts of Tibouchina candolleana as well as the evaluation of the antimicrobial activity of extracts, isolated compounds, and semi-synthetic derivatives of ursolic acid against endodontic bacteria. HRGC analysis of the n-hexane extract of T. candolleana allowed identification of b-amyrin, a-amyrin, and b-sitosterol as major constituents. The triterpenes ursolic acid and oleanolic acid were isolated from the methylene chloride extract and identified. In addition, the flavonoids luteolin and genistein were isolated from the ethanol extract and identified. The antimicrobial activity was investigated via determination of the minimum inhibitory concentration (MIC) using the broth... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tibouchina candolleana; Ursolic acid; Antimicrobial activity. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000200045 |
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| Cargnin,Simone Tasca; Staudt,Andressa Finkler; Menezes,Camila; Azevedo,Ana Paula de; Fialho,Saara Neri; Tasca,Tiana; Teles,Carolina Bioni Garcia; Gnoatto,Simone Baggio. |
| Trichomonas vaginalis and Leishmania spp. are protozoal species responsible for millions of cases of parasitic diseases worldwide. Considering the potential of natural products and the need for more effective and less toxic alternatives to treat trichomoniasis and leishmaniasis, this study aimed to evaluate the effect of two series of triterpenes derivatives with different modifications at C-3 and C-28 positions of the ursolic acid (UA) and betulinic acid (BA) against trophozoites of Trichomonas vaginalis and promastigotes forms of Leishmania (L.) amazonensis. The compounds modified just at C-3 were the most active. The 3β-acetyl betulinic acid (1b) reduced the trophozoites viability of T. vaginalis at 74%, followed by the 3-oxo ursolic acid and 3-oxo... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Betulinic acid; Leishmania amazonensis; Semisynthesis; Trichomonas vaginalis; Ursolic acid. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100596 |
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| ZHANG, Feng; DAIMARU, Eisuke; OHNISHI, Masao; KINOSHITA, Mikio; TOKUJI, Yoshihiko; 得字, 圭彦. |
| Oleanolic acid (OA) and ursolic acid (UA) are natural triterpenoids that have preventive properties such as anti-tumor and anti-hepatitis activities. These triterpenes are known to exist in several medicinal plants and fruit skins. Dried fruits are usually eaten without removing the skin; thus, they may be good resources for oral intake of OA and UA. HPLC analysis of OA and UA contents in a variety of dried fruits showed that raisins contained higher levels of OA than the other fruits investigated, with green raisins containing the highest levels (79.0 mg/100 g). While raisins were found to contain only OA, dried cranberries, blueberries and cherries were shown to contain both OA and UA. The highest level of UA (65.9 mg/100 g) was detected in cranberries,... |
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Palavras-chave: Oleanolic acid; Ursolic acid; Dried fruits; Raisins; Cranberries. |
| Ano: 2013 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3902 |
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