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	Provedor de dados BJMBR (2) BABT (1) Autor Araújo,Elaine Bortoleti de (1) Bakken,I.J. (1) Calixto,J.B. (1) Campestrini,F.D. (1) Colturato,Maria Tereza (1) Cunha,J.F. (1) Muramoto,Emiko (1) Paulino,N. (1) Scremin,A. (1) Sjaavaag,I. (1) Vincent,M.B. (1) White,L.R. (1) Mais... Palavra-chave VIP (3) Acetylcholine (1) Adenocarcinomas (1) CGRP (1) Digitalization (1) Gentisic acid (1) Potassium channels (1) Protein radioiodination (1) Radiopharmaceuticals (1) Smooth muscle (1) Substance P (1) Trachea (1) VIP10-28 (1) Vasoactive intestinal peptide (1) Vasoactivity (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Info:eu-repo/semantics/other (1) Ano 2005 (1) 2001 (1) 1997 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Comparative biodistribution profile of [131I]VIP and [131I]VIP10-28 BABT Colturato,Maria Tereza; Muramoto,Emiko; Araújo,Elaine Bortoleti de. Various tumor cells express significantly higher amounts of VIP receptors (VIPR) that provided the basis for the clinical use of radiolabeled VIP for the in vivo localization of tumors. This work studied the labeling of VIP and VIP10-28 with iodine-131 to compare the biological distribution of the labeled compounds in Nuce mice and the affinity for tumor cells. Both VIP and VIP10-28 peptides contain two tyrosine residues, in positions 10 and 22, that are theoretically equally susceptible to radioiodination employing oxidative electrophilic substitution using oxidizing agents like Chloramine T. Radiochemical purity of the reaction mixture was determined by electrophoresis and HPLC. The VIP peptide and the fragment were labeled with radioiodine with good... Tipo: Info:eu-repo/semantics/article Palavras-chave: Radiopharmaceuticals; Protein radioiodination; VIP; VIP10-28; Adenocarcinomas. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700012 The mechanism of gentisic acid-induced relaxation of the guinea pig isolated trachea: the role of potassium channels and vasoactive intestinal peptide receptors BJMBR Cunha,J.F.; Campestrini,F.D.; Calixto,J.B.; Scremin,A.; Paulino,N.. We examined some of the mechanisms by which the aspirin metabolite and the naturally occurring metabolite gentisic acid induced relaxation of the guinea pig trachea in vitro. In preparations with or without epithelium and contracted by histamine, gentisic acid caused concentration-dependent and reproducible relaxation, with mean EC50 values of 18 µM and Emax of 100% (N = 10) or 20 µM and Emax of 92% (N = 10), respectively. The relaxation caused by gentisic acid was of slow onset in comparison to that caused by norepinephrine, theophylline or vasoactive intestinal peptide (VIP). The relative rank order of potency was: salbutamol 7.9 > VIP 7.0 > gentisic acid 4.7 > theophylline 3.7. Gentisic acid-induced relaxation was markedly reduced (24 ± 7.0, 43... Tipo: Info:eu-repo/semantics/article Palavras-chave: Gentisic acid; Potassium channels; Vasoactive intestinal peptide; VIP; Trachea; Smooth muscle. Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300013 Computerized analysis of isometric tension studies provides important additional information about vasomotor activity BJMBR Vincent,M.B.; White,L.R.; Bakken,I.J.; Sjaavaag,I.. Concentration-response curves of isometric tension studies on isolated blood vessels are obtained traditionally. Although parameters such as Imax, EC50 and pA2 may be readily calculated, this method does not provide information on the temporal profile of the responses or the actual nature of the reaction curves. Computerized data acquisition systems can be used to obtain average data that represent a new source of otherwise inaccessible information, since early and late responses may be observed separately in detail Tipo: Info:eu-repo/semantics/other Palavras-chave: Vasoactivity; Digitalization; Substance P; Acetylcholine; VIP; CGRP. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000015 Registros recuperados: 3 Primeira ... 1 ... Última

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