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| Lee,Jae Eun; Kim,Jung Hwa. |
| Abstract Valproic acid (VPA) is a clinically available histone deacetylase inhibitor with promising anticancer attributes. Recent studies have demonstrated the anticancer effects of VPA on prostate cancer cells. However, little is known about the differential effects of VPA between metastatic and non-metastatic prostate cancer cells and the relationship between the expression of metastasis suppressor proteins and VPA. In the present study, we demonstrate that inhibition of cell viability and invasion by VPA was more effective in the metastatic prostate cancer cell line PC3 than in the tumorigenic but non-metastatic prostate cell line, RWPE2. Further, we identified that the metastasis suppressor NDRG1 is upregulated in PC3 by VPA treatment. In contrast,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: VPA; NDRG1; Prostate cancer cells. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000400527 |
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| Fromentin, Jean-marc; Kell, Laurence T. |
| An integrative simulation framework was built to evaluate the consequences of variability attributable to changes in carrying capacity or the stock’s migration pattern of Atlantic bluefin tuna on the ICCAT stock assessment and management procedures. We also evaluated the performances of stock assessment methods with respect to their ability to provide good estimates of MSY, FMSY and BMSY and tested the robustness of the current ICCAT management strategy to uncertainty about the true dynamics and historical exploitation levels. The results clearly indicate that the VPA performances were seriously impaired if the long-term variations in catches are due to changes in migration/availability. There is further considerable confounding between the underlying... |
| Tipo: Text |
Palavras-chave: Thunnus thynnus; Stock assessment; VPA; Biological reference points; MSY; Management strategy; Simulation model. |
| Ano: 2009 |
URL: http://archimer.ifremer.fr/doc/00192/30295/28786.pdf |
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| Bonhommeau, Sylvain; Fromentin, Jean-marc. |
| This study aims at examining the potential bias in the VPA estimates by simulating a population, catch and CPUEs over 39 years from 1970 to 2008. In the operational model, two levels of noise were added to catch and CPUEs (50 and 100%), three fishing patterns were explored (F=FMSY, F increases linearly from 0.5 FMSY to 2.5 FMSY, F increases linearly from 0.5 FMSY to 2.5 FMSY over the first 34 years and decreases down to FMSY over the last 5 years). We also tested different hypothesis about the impact of the terminal F-ratios, and the natural mortality used in the current VPA as well as the impact of randomly generated CPUE for long-line and trap CPUE. Results show that the VPA is robust to estimate the SSB whatever the noise level in the catch and the... |
| Tipo: Text |
Palavras-chave: Bluefin tuna; Stock assessment; VPA; Management regulations; TAC. |
| Ano: 2011 |
URL: http://archimer.ifremer.fr/doc/00192/30280/28755.pdf |
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| Reis,K.P.; Sperling,L.E.; Teixeira,C.; Sommer,L.; Colombo,M.; Koester,L.S.; Pranke,P.. |
| The central nervous system shows limited regenerative capacity after injury. Spinal cord injury (SCI) is a devastating traumatic injury resulting in loss of sensory, motor, and autonomic function distal from the level of injury. An appropriate combination of biomaterials and bioactive substances is currently thought to be a promising approach to treat this condition. Systemic administration of valproic acid (VPA) has been previously shown to promote functional recovery in animal models of SCI. In this study, VPA was encapsulated in poly(lactic-co-glycolic acid) (PLGA) microfibers by the coaxial electrospinning technique. Fibers showed continuous and cylindrical morphology, randomly oriented fibers, and compatible morphological and mechanical... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Coaxial electrospinning; VPA; Spinal cord injury. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000400606 |
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