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	Provedor de dados Acta biol.Colomb. (1) BJMBR (1) BJM (1) Genet. Mol. Biol. (1) Autor Calamante,Gabriela (1) Chiarini,L.B. (1) Chiodo,V. (1) Conte Grand,María Daniela (1) Hauswirth,W.W. (1) Linden,R. (1) Linden,Rafael (1) Matte,Ursula (1) Mitarotonda,Romina Cristina (1) NAVAS,Maria-Cristina (1) PAVLOVIC,Jovan (1) Petrs-Silva,H. (1) STOLL-KELLER,Françoise (1) Taboga,Oscar Alberto (1) Zanetti,Flavia Adriana (1) Mais... Palavra-chave Viral vector (4) Gene therapy (2) Canarypox virus (1) Dendritic cells (1) Gene delivery (1) Gene transfer (1) HCV (1) IBDV (1) Max expression (1) Neuroprotection (1) Retina (1) SFV (1) South America (1) Transcription factor (1) VP2 protein (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Info:eu-repo/semantics/other (2) Ano 2019 (1) 2014 (2) 2005 (1) País Brazil (3) Colombia (1) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última A snapshot of gene therapy in Latin America Genet. Mol. Biol. Linden,Rafael; Matte,Ursula. Gene therapy attempts the insertion and expression of exogenous genetic material in cells for therapeutic purposes. Conceived in the 1960s, gene therapy reached its first clinical trial at the end of the 1980s and by December 2013 around 600 genuine open clinical trials of gene therapy were registered at NIH Clinical Trials Database. Here, we summarize the current efforts towards the development of gene therapy in Latin America. Our survey shows that the number of scientists involved in the development of gene therapy and DNA vaccines in Latin America is still very low. Higher levels of investment in this technology are necessary to boost the advancement of innovation and intellectual property in this field in a way that would ease both the social and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Gene therapy; Gene transfer; Gene delivery; Viral vector; South America. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000200015 LACK OF EXPRESSION OF HEPATITIS C VIRUS CORE PROTEIN IN HUMAN MONOCYTE-DERIVED DENDRITIC CELLS USING RECOMBINANT SEMLIKI FOREST VIRUS Acta biol.Colomb. NAVAS,Maria-Cristina; STOLL-KELLER,Françoise; PAVLOVIC,Jovan. ABSTRACT Hepatitis C Virus belongs to the Flaviviridae family. One proposed mechanism of HCV persistence in the ability to infect hematopoietic cells, including Dendritic cells (DCs). HCV infection of DCs could impair their functions that represent one of the mechanisms, thus hampering viral clearance by the host immune system. Among HCV-encoded proteins, the highly conserved Core protein has been suggested to be responsible for the immunomodulatory properties of this Hepacivirus. Recombinant viral vectors expressing the HCV Core protein and allowing its transduction and therefore the expression of the protein into DCs could be useful tools for the analysis of the properties of the Core protein. Vaccinia Virus and retrovirus have been used to transduce... Tipo: Info:eu-repo/semantics/article Palavras-chave: Dendritic cells; HCV; SFV; Viral vector. Ano: 2019 URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2019000300493 Modulation of the expression of the transcription factor Max in rat retinal ganglion cells by a recombinant adeno-associated viral vector BJMBR Petrs-Silva,H.; Chiodo,V.; Chiarini,L.B.; Hauswirth,W.W.; Linden,R.. Exclusion of the transcription factor Max from the nucleus of retinal ganglion cells is an early, caspase-independent event of programmed cell death following damage to the optic axons. To test whether the loss of nuclear Max leads to a reduction in neuroprotection, we developed a procedure to overexpress Max protein in rat retinal tissue in vivo. A recombinant adeno-associated viral vector (rAAV) containing the max gene was constructed, and its efficiency was confirmed by transduction of HEK-293 cells. Retinal ganglion cells were accessed in vivo through intravitreal injections of the vector in rats. Overexpression of Max in ganglion cells was detected by immunohistochemistry at 2 weeks following rAAV injection. In retinal explants, the preparation of... Tipo: Info:eu-repo/semantics/other Palavras-chave: Retina; Max expression; Transcription factor; Viral vector; Gene therapy; Neuroprotection. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000300008 Canarypox virus expressing infectious bursal disease VP2 protein as immunogen for chickens BJM Zanetti,Flavia Adriana; Conte Grand,María Daniela; Mitarotonda,Romina Cristina; Taboga,Oscar Alberto; Calamante,Gabriela. Canarypox viruses (CNPV) carrying the coding sequence of VP2 protein from infectious bursal disease virus (IBDV) were obtained. These viruses were able to express VP2 protein in vitro and to induce IBDV-neutralizing antibodies when inoculated in specific pathogen-free chickens demonstrating that CNPV platform is usefulness to develop immunogens for chickens. Tipo: Info:eu-repo/semantics/other Palavras-chave: Canarypox virus; Viral vector; IBDV; VP2 protein. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000100032 Registros recuperados: 4 Primeira ... 1 ... Última

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