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| Rungsa,Prapenpuksiri; Incamnoi,Paroonkorn; Sukprasert,Sophida; Uawonggul,Nunthawun; Klaynongsruang,Sompong; Daduang,Jureerut; Patramanon,Rina; Roytrakul,Sittiruk; Daduang,Sakda. |
| Abstract Background: Wasp venom is a complex mixture containing proteins, enzymes and small molecules, including some of the most dangerous allergens. The greater banded wasp (Vespa tropica) is well-known for its lethal venom, whose one of the major components is a hyaluronidase (HAase). It is believed that the high protein proportion and activity of this enzyme is responsible for the venom potency. Methods: In the present study, cDNA cloning, sequencing and 3D-structure of Vespa tropica venom HAase were described. Anti-native HAase antibody was used for neutralization assay. Results: Two isoforms, VesT2a and VesT2b, were classified as members of the glycosidase hydrolase 56 family with high similarity (42–97 %) to the allergen venom HAase. VesT2a gene... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Wasp venom; Vespa tropica; Hyaluronidase (HAase). |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100321 |
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