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| Shi,Jianli; Mei,Wenyan; Yang,Jing. |
| As the key component of many hemoproteins (heme-containing proteins), heme is involved in a broad range of biological processes. Enzymes required for heme biosynthesis and degradation pathways are evolutionarily conserved. While heme metabolism has been studied extensively, the expression of heme metabolism enzymes during development has not been described. Here, we report that all heme biosynthases and two heme oxygenases, which initiate heme degradation, are dynamically expressed during Xenopus embryonic development. All heme synthases, with the exception of aminolevulinic acid synthase 2, are maternally expressed. At neurula stage, heme synthases are expressed in the developing neural tissue and in migrating neural crest cells. At the swimming tadpole... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Heme synthases; Heme oxygenases; Development; Xenopus. |
| Ano: 2008 |
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452008000300007 |
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| Fujitani,Kazuko; Otomo,Asako; Nagayama,Yuto; Tachibana,Taro; Kato,Rika; Kawashima,Yusuke; Kodera,Yoshio; Kato,Tomoko; Takada,Shuji; Tamura,Kei; Takamatsu,Nobuhiko; Ito,Michihiko. |
| Abstract The transcription factor DMRT1 (doublesex and mab-3 related transcription factor) has two distinct functions, somatic-cell masculinization and germ-cell development in some vertebrate species, including mouse and the African clawed frog Xenopus laevis. However, its transcriptional regulation remains unclear. We tried to identify DMRT1-interacting proteins from X. laevis testes by immunoprecipitation with an anti-DMRT1 antibody and MS/MS analysis, and selected three proteins, including PACT/PRKRA (Interferon-inducible double-stranded RNA dependent protein kinase activator A) derived from testes. Next, we examined the effects of PACT/PRKRA and/or p53 on the transcriptional activity of DMRT1. In transfected 293T cells, PACT/PRKRA and p53... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: P53; DMRT1; Germline stem cell; Testis; Xenopus. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000400702 |
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