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| Schüler-Faccini,Lavinia; Sanseverino,Maria Teresa Vieira; Abeche,Alberto Mantovani; Vianna,Fernanda Sales Luiz; Fraga,Lucas Rosa; Rocha,Anastacia Guimaraes; Silva,André Anjos da; Souza,Paulo Ricardo Assis de; Hilgert,Artur Hartmann; Barbosa,Camila Pocharski; Kauppinem,Caroline Grasso; Martins,Daniela Fernandes; Santos,Daniela Silva; Colpes,Gabriel Henrique; Ecco,Gabriela; Silva,Helena Margot Flores Soares da; Penteado,Louise Piva; Santos,Tatiane dos. |
| Abstract In 1990, the first Teratogen Information Service in Brazil (SIAT) was implemented in the Medical Genetics Service at Hospital de Clinicas de Porto Alegre. SIAT is a free-to-use information service both to health professionals and the general population, especially to women who are pregnant or planning pregnancy. The main objective of this paper is to present the activities of SIAT in its initial years (1990-2006), compared to those in the last decade (2007-2017). In addition we review the scientific contribution of SIAT in the field of human teratogenesis. Since 1990, SIAT received 10,533 calls. Use of medications were the main reason for concern, accounting for 74% of all questions, followed by other chemical exposures (occupational, cosmetics,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Teratogens; Pregnancy; Zika; Thalidomide; Misoprostol; Rubella. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000200297 |
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| Silva,William Ribeiro da; Soares-da-Silva,Joelma; Ferreira,Francisco Augusto da Silva; Rodrigues,Iléa Brandão; Tadei,Wanderli Pedro; Zequi,João Antonio Cyrino. |
| ABSTRACT The aim of this study was to analyze the effectiveness of different control agents of Aedes aegypti and Aedes albopictus associated with ovitraps under laboratory and field conditions. Five treatments were used: grass infusion + Bacillus thuringiensis israelensis (gI + Bti), grass infusion + Saccharopolyspora spinosa (gI + Ss), grass infusion + Pyriproxyfen (gI + P), distilled water + Toxorhynchites haemorrhoidalis (dW + Th), and grass infusion (gI) (control). The highest mean number of eggs of both species were obtained with grass infusion in the laboratory. Among control agents, the lowest mean of A. aegypti eggs occurred with gI + Ss and the lowest mean of A. albopictus eggs occurred with dW + Th. There was no difference between treatments in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chikungunya; Control; Dengue; Insecticides; Zika. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0085-56262018000400304 |
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| Brito,Joás; Louback-Franco,Nayara; Mendoza,Cristian; Nonato,Flávia; Juen,Leandro; Michelan,Thaisa. |
| Abstract The struggle to control insect-borne diseases can lead to make rash decisions. For instance, the controversial method of planting of Crotalaria spp. to attract predatory dragonflies can be used to control insect vectors of dengue fever and several other medically significant insect-borne diseases. Nevertheless, there is no scientific support for this assumption. Despite the lack of evidence, in Brazil, there remains a multitude of online articles and grey literature sources still promote Crotalaria planting as a means to prevent dengue fever. Here we discuss the reasons why Odonata would not be attracted by Crotalaria and, therefore, it cannot not be considered as an efficient method for vector control. Finally, the best practice to avoid the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mosquitoes; Tropical diseases; Zika; Invasive species. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-06032020000200401 |
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| Mota,Mânlio Tasso de Oliveira; Terzian,Ana Carolina; Silva,Maria Luana Cristiny Rodrigues; Estofolete,Cássia; Nogueira,Maurício Lacerda. |
| ABSTRACT Arboviruses pose a serious threat to public health worldwide, overloading the healthcare system and causing economic losses. These viruses form a very diverse group, and in Brazil, arboviruses belonging to the families Flaviviridae and Togaviridae are predominant. Unfortunately, the number of arboviruses increases in proportion with factors such as deforestation, poor sanitation, climate changes, and introduction of new viruses like Chikungunya virus and Zika virus. In Brazil, dengue is endemic, along with the presence of other arboviruses. The situation is complicated by the scarcity of diagnostic infrastructure and the absence of approved vaccines for these diseases. Disease control, thus, relies solely on vector control. Therefore, enhanced... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Arboviruses; Dengue; Chikungunya; Mayaro; Zika. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000500038 |
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| Mottin,Melina; Borba,Joyce Villa Verde Bastos; Melo-Filho,Cleber Camilo; Neves,Bruno Junior; Muratov,Eugene; Torres,Pedro Henrique Monteiro; Braga,Rodolpho Campos; Perryman,Alexander; Ekins,Sean; Andrade,Carolina Horta. |
| Few Zika virus (ZIKV) outbreaks had been reported since its first detection in 1947, until the recent epidemics occurred in South America (2014/2015) and expeditiously became a global public health emergency. This arbovirus reached 0.5-1.3 million cases of ZIKV infection in Brazil in 2015 and rapidly spread in new geographic areas such as the Americas. Despite the mild symptoms of the Zika fever, the major concern is related to the related severe neurological disorders, especially microcephaly in newborns. Advances in ZIKV drug discovery have been made recently and constitute promising approaches to ZIKV treatment. In this review, we summarize current computational drug discovery efforts and their applicability to discovery of anti-ZIKV drugs. Lastly, we... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Zika; Flavivirus Antiviral; Computer-assisted drug design; Virtual screening; Drug discovery. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000700401 |
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