|
|
|
| Registros recuperados: 23 | |
|
| |
|
|
| Michael Dean; Latoya Silverton; Julie Sawitzke. |
| Breast cancer is the most common cancer among American women. Any woman can be affected by breast cancer, with risk for the disease increasing with age. Risk for breast cancer is also exacerbated in women who have certain genetic alterations. Mutations in the BRCA1 and BRCA2 genes predispose women to breast and ovarian cancer, and are increasingly recognized in prostate and pancreatic cancers (1-3). In Caucasian and Asian ethnicities BRCA mutations are associated with basal-type/triple-negative disease. However this association between BRCA gene mutations and basal/triple-negative disease has been understudied in other ethnicities (4-6). The incidence and mortality of breast cancer of Hispanics and Native Americans are lower than other ethnicities;... |
| Tipo: Marker Paper / Data Plan |
Palavras-chave: Cancer; Genetics & Genomics; Immunology; Bioinformatics. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5691/version/1 |
| |
|
| |
|
|
| Claire M. Fraser-Liggett; Alan R. Shuldiner. |
| Emerging evidence that the gut microbiota may contribute in important ways to human health and disease has led us and others to hypothesize that both symbiotic and pathological relationships between gut microbes and their host may by key contributors to obesity and the metabolic complications of obesity. Our “Thrifty Microbiome Hypothesis” posits that gut microbiota play a key role in human energy homeostasis. Specifically, constituents of the gut microbial community may introduce a survival advantage to its host in times of nutrient scarcity, promoting positive energy balance by increasing efficiency of nutrient absorption and improving metabolic efficiency and energy storage. However, in the presence of excess nutrients, fat... |
| Tipo: Marker Paper / Data Plan |
Palavras-chave: Genetics & Genomics; Data Standards. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4957/version/1 |
| |
|
|
| Jacques Ravel; Larry J. Forney. |
| The vaginal microbiota play an important protective role in maintaining the health of women. Disruption of the mutualistic relationship that exists between bacterial communities in the vagina and their hosts can lead to bacterial vaginosis (BV), a condition in which lactic acid producing bacteria are supplanted by a diverse array of strictly anaerobic bacteria. BV has been shown to be an independent risk factor for adverse outcomes including preterm delivery and low infant birth weight, acquisition of sexually transmitted infections and HIV, and development of pelvic inflammatory disease. National surveys indicate the prevalence of BV among U.S. women is 29.2%, and yet, despite considerable effort, the etiology of BV remains unknown. Moreover, there are no... |
| Tipo: Marker Paper / Data Plan |
Palavras-chave: Ecology; Microbiology; Bioinformatics; Data Standards. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5062/version/1 |
| |
|
|
| Julia Segre; Heidi Kong. |
| The Human Microbiome Project seeks to explore the diversity of microbiota that resides in and on the human body, including the skin, in health and disease. The NIH Intramural Skin Microbiome Consortium (NISMC) is a trans-disciplinary group of experts engaged in the practice of genomics, bioinformatics, large-scale DNA sequencing, dermatology, immunology, allergy, infectious disease, and clinical microbiology. Atopic dermatitis (AD, “eczema”) is a chronic relapsing skin disorder that affects ~15% of U.S. children and is associated with $1 billion of medical costs annually. AD is characterized by dry, itchy skin, infiltrated with immune cells. Colonization by _Staphylococcus aureus_ (_S. aureus_) is ten-fold more common in AD patients... |
| Tipo: Marker Paper / Data Plan |
Palavras-chave: Genetics & Genomics; Microbiology; Data Standards. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5019/version/1 |
| |
|
| |
|
|
| Michael Dean; Latoya Silverton; Julie Sawitzke. |
| Breast cancer is the most common cancer among American women. Any woman can be affected by breast cancer, with risk for the disease increasing with age. Risk for breast cancer is also exacerbated in women who have certain genetic alterations. Mutations in the BRCA1 and BRCA2 genes predispose women to breast and ovarian cancer, and are increasingly recognized in prostate and pancreatic cancers (1-3). In Caucasian and Asian ethnicities BRCA mutations are associated with basal-type/triple-negative disease. However this association between BRCA gene mutations and basal/triple-negative disease has been understudied in other ethnicities (4-6). The incidence and mortality of breast cancer of Hispanics and Native Americans are lower than other ethnicities;... |
| Tipo: Marker Paper / Data Plan |
Palavras-chave: Cancer; Genetics & Genomics; Bioinformatics; Data Standards. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5691/version/2 |
| |
|
| |
|
| |
|
|
| Claire M. Fraser-Liggett. |
| Inflammatory bowel diseases (IBD), such as Crohn’s disease, are chronic, immunologically mediated disorders that have severe medical consequences. The current hypothesis is that these diseases are due to an overly aggressive immune response to a subset of commensal enteric bacteria. Studies to date on IBD have suggested that the disorder may be caused by a combination of bacteria and host susceptibility; however the etiologies of these diseases remain an enigma. In this application, we propose to develop and demonstrate the ability to profile Crohn’s disease at an unprecedented molecular level by elucidation of specific biomarkers (bacterial strains, genes, or proteins) that correlate to disease symptoms. To achieve this goal, we will... |
| Tipo: Marker Paper / Data Plan |
Palavras-chave: Genetics & Genomics; Data Standards. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4958/version/1 |
| |
|
|
| Huiying Li. |
| The human microbiota contributes to our normal postnatal development and plays a significant role in defining our physiology. To understand the role of microbiota in human health and disease, we study the skin microbiome in pilosebaceous units (hair follicles) and its association with acne.

Acne is one of the most common skin diseases. Although its etiology still needs to be defined, a bacterial factor has been suggested in the development of the disease. In fact, antibiotic therapy targeting _Propionibacterium acnes_ has been a mainstay treatment for more than 30 years.

Our preliminary study shows that the microcomedone, a specialized skin compartment where acne arises, has a tractable... |
| Tipo: Marker Paper / Data Plan |
Palavras-chave: Genetics & Genomics; Microbiology; Bioinformatics; Data Standards. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5305/version/1 |
| |
|
| |
|
| |
|
| |
|
| |
|
|
| J. Dennis Fortenberry; David E. Nelson; Qunfeng Dong. |
| Project ID: 46317 – No publication moratorium. 

The microflora of the anterior male urethra during adolescence is poorly described and no data address the range of “typical” urethral organisms during adolescence as functions of pubertal development or onset of various types of partnered sexual activity. This means that current understanding of the urethral microbiome in adolescent men rests entirely on limited data inferred from adults, and from epidemiologic and behavioral explanations. Marked ethnic group variation in adolescent sexual behaviors and disparity in conditions such as sexually transmitted infections (STI) justifies exploration of potential ethnic group differences in the... |
| Tipo: Marker Paper / Data Plan |
Palavras-chave: Microbiology; Data Standards. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5221/version/1 |
| |
|
| |
|
| |
|
| |
| Registros recuperados: 23 | |
|
|
|
