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Ringwald, Pascal; Bickii, J.; Basco, L.. |
The in vitro activity of nine antimalarials was determined against 119 fresh clinical isolates of #Plasmodium falciparum$ obtained from symptomatic indigenous patients in Yaounde, Cameroun, using the isotopic semimicrotest. Seventy-four parasites were resistant to chloroquine (mean 50% inhibitory concentration [IC50] 337 nM) ; 45 were chloroquine-sensitive (mean IC50 35.6 nM). Twenty-five of 58 chloroquine-resistant parasites were resistant to monodesethylamodiaquine, the biologically active metabolite of amodiaquine. None of the chloroquine-sensitive isolates was resistant to monodesethylamodiaquine (IC50 17.3 nM). Pyronaridine, quinine, mefloquine, halofantrine, and artemether were highly active against the chloroquine-sensitive and the... |
Tipo: Text |
Palavras-chave: PALUDISME; AGENT PATHOGENE; SENSIBILITE RESISTANCE; MEDICAMENT; EFFICACITE; CHLOROQUINE; MONODESETHYLAMODIAQUINE; PYRONARIDINE; QUININE; MEFLOQUINE; HALOFANTRINE; ARTEMETHER; CYCLOGUANIL; PYRIMETHAMINE; SCHEMA THERAPEUTIQUE. |
Ano: 1996 |
URL: http://www.documentation.ird.fr/hor/fdi:010007534 |
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Fievet, Nadine; Cot, Michel; Chougnet, C.; Maubert, B.; Bickii, J.; Dubois, B.; Le Hesran, Jean-Yves; Frobert, Y.; Migot, F.; Romain, F.; Verhave, J.P.; Louis, F.; Deloron, Philippe. |
Tipo: Text |
Palavras-chave: PALUDISME; GROSSESSE; EPIDEMIOLOGIE; IMMUNITE; SEROLOGIE; ANTICORPS; ANTIGENE. |
Ano: 1995 |
URL: http://www.documentation.ird.fr/hor/fdi:010004231 |
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