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| Soares, Pedro; Froufe, Hugo J.C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Borges, Fernanda; Queiroz, Maria João R.P.. |
| The development of anticancer drugs inhibiting angiogenesis has been an area of extensive research in the past decade. Angiogenesis is a requirement for tumor growth and metastasis and occurs through several signalling pathways. One key pathway that initiates proliferation and migration of endothelial cells is signalling through the vascular endothelial growth factor receptor-2 (VEGFR-2).1 Therefore, small molecules that block this signalling pathway through inhibition of VEGFR-2 tyrosine kinase activity could potentially inhibit angiogenesis and tumor growth. Recently works describing thienopyrimidine2 and thienopyrimidine 1,3-diarylureas3 as VEGFR-2 inhibitors have emerged in the literature. Here we present the synthesis of new... |
| Tipo: ConferenceObject |
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| Ano: 2011 |
URL: http://hdl.handle.net/10198/6079 |
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| Soares, Pedro; Froufe, Hugo J.C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Borges, Fernanda; Queiroz, Maria João R.P.. |
| Angiogenesis is a requirement for tumor growth and metastasis and occurs through several signalling pathways. One key pathway that initiates proliferation and migration of endothelial cells is signalling through the vascular endothelial growth factor receptor-2 (VEGFR-2).1 Therefore, small molecules that block this signalling pathway through inhibition of the VEGFR tyrosine kinase activity could potentially inhibit angiogenesis and tumour growth. Recently works describing thienopyrimidines2 and thienopyridine ureas3 as inhibitors of VEGFR-2 have appeared in the literature. Here we present the synthesis of new 1,3-diarylureas 2 starting by regioselective nucleophilic substitution of the 4-chlorothieno[3,2-d]pyrimidine with 4-aminophenol to obtain... |
| Tipo: ConferenceObject |
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| Ano: 2011 |
URL: http://hdl.handle.net/10198/6077 |
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| Silva, Artur; Santos, Clementina M.M.; Cavaleiro, José; Tavares, Hilário; Borges, Fernanda; Silva, Francisco. |
| Phenolic compounds are the most abundant c1ass of natural antioxidants. These types of compounds are ubiquitous in fruits and vegetables and in plant-derived beverages, such tea and wine, being important constituents of human diet. Recent studies have pointed out particular interest on phenolic type compounds (e.g. flavonoids, catechins, cinnamic and benzoic acid derivatives) with respect not on1y to the organoleptic characteristics of foodstuffs (e.g. flavour, bitterness, astringency) but also to their potential benefits in deleterious oxidative radicalar processes related with human disease (e.g. cancer, atherosc1erosis).l,2 The antioxidant activity of phenolic compounds could be related with their antiradicalar activity and/or with the ability to act as... |
| Tipo: ConferenceObject |
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| Ano: 2000 |
URL: http://hdl.handle.net/10198/3798 |
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