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A Single High Dose of Chlorpyrifos Reduces Long-Term Basal C-Fos Expression in the Rat Arcuate Hypothalamic Nucleus International Journal of Morphology
Carvajal,F; Lerma-Cabrera,J. M; Sánchez-Amate,M. C; Cubero,I.
Chlorpyrifos (CPF) is an organophosphate compound used worldwide as a pesticide in agriculture that, after subcutaneous injection, keeps acetylcholinesterase (AChE) activity inhibited within an organism for months. Ample clinical and experimental evidence shows that CPF exposure induces relevant and persistent neurobehavioral deficits in humans and animals, even after one single episode/injection. Additionally, clinical and epidemiological studies evidence that a significant percentage (60%) of Gulf War veterans as well as agricultural workers suffering from acute OP intoxication may have developed intolerance to nicotine and ethanol-containing beverages. Consistent with it, administration of a single high dose of CPF to adult Wistar rats elicited...
Tipo: Journal article Palavras-chave: Chlorpyrifos; Organophosphates; C-fos expression; Arcuate hypothalamic nucleus; Ethanol consumption.
Ano: 2014 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000100015
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