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Association between the c.910A>G genetic variant of the XRCC1 gene and susceptibility to esophageal cancer in the Chinese Han population BJMBR
Chen,X.Q.; Wang,F.; Zheng,Y.L.; Fan,Q.X.; Yue,D.L.; Ma,Z.J..
Esophageal cancer (EC) is a common malignancy worldwide. The X-ray repair cross-complementing 1 gene (XRCC1) is one of the most important candidate genes for influencing susceptibility to EC. This study aimed to investigate the effect of XRCC1 genetic variants on susceptibility to EC. A total of 383 EC patients (males: 239, females: 144, mean age: 56.62) and 387 cancer-free controls (males: 251, females: 136, mean age: 58.23) were enrolled in this study. The c.910A>G genetic variant of theXRCC1 gene was determined by polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing methods. The allele and genotype frequencies indicated statistical differences between EC patients and cancer-free controls. The c.910A>G genetic...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Esophageal cancer; XRCC1 gene; Genetic variant; Molecular marker; Susceptibility.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001201028
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Cytotoxicity of Marchantia convoluta leaf extracts to human liver and lung cancer cells BJMBR
Xiao,J.B.; Chen,X.Q.; Zhang,Y.W.; Jiang,X.Y.; Xu,M..
The cytotoxicity of three extracts (petroleum ether, ethyl acetate and n-butanol) from a plant used in folk medicine, Marchantia convoluta, to human non-small cell lung carcinoma (H1299) and liver carcinoma (HepG2) cell lines was tested. After 72-h incubation of lung and liver cancer cell cultures with varying concentrations of extracts (15 to 200 µg/mL), cytotoxicity was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and reported in terms of cell viability. The extracts that showed a significant cytotoxicity were subjected to gas chromatography-mass spectrometry analysis to identify the components. The ethyl acetate, but not the petroleum ether or n-butanol extract, had a significant cytotoxicity against lung and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Marchantia convoluta extract; Cytotoxicity assay; HepG2 and H1299 carcinoma cell lines; Phytol; Caryophyllene oxide.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000600005
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