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Registros recuperados: 3
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Effects of chronic heart disease on skeletal muscle fiber size BJMBR
Mattiello-Sverzut,A.C.; Chimelli,L.; Teixeira,S.; Pierre,M.; Oliveira,L..
Size changes in muscle fibers of subjects with chronic heart disease (CHD) have been reported, although a consensus has not been achieved. The aims of the present study were to investigate a possible association between CHD and fiber size changes in the brachial biceps compared to subjects without heart disease. Forty-six muscle samples were obtained in autopsies of individuals (13 to 84 years) without neuromuscular disorders, 19 (10 males and 9 females) with, and 27 (14 males and 13 females) without CHD. In all cases muscle sections were stained with hematoxylin and eosin and processed for the visualization of myofibrillar ATPase activity. The lesser diameter of type 1 and type 2 fibers was obtained tracing their outlines (at least 150 fibers of each type...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Morphometry; Brachial biceps; Chronic heart disease; Post mortem muscle; Type 1 fiber hypertrophy; Type 2 fiber hypertrophy.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000200019
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Myosin Va is developmentally regulated and expressed in the human cerebellum from birth to old age BJMBR
Souza,C.C.R.; Dombroski,T.C.D.; Machado,H.R.; Oliveira,R.S.; Rocha,L.B.; Rodrigues,A.R.A.; Neder,L.; Chimelli,L.; Corrêa,V.M.A.; Larson,R.E.; Martins,A.R..
Myosin Va functions as a processive, actin-based motor molecule highly enriched in the nervous system, which transports and/or tethers organelles, vesicles, and mRNA and protein translation machinery. Mutation of myosin Va leads to Griscelli disease that is associated with severe neurological deficits and a short life span. Despite playing a critical role in development, the expression of myosin Va in the central nervous system throughout the human life span has not been reported. To address this issue, the cerebellar expression of myosin Va from newborns to elderly humans was studied by immunohistochemistry using an affinity-purified anti-myosin Va antibody. Myosin Va was expressed at all ages from the 10th postnatal day to the 98th year of life, in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Myosin Va; Human cerebellum; Postnatal development; Aging; Immunohistochemical expression.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000200164
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Quantitative evidence for neurofilament heavy subunit aggregation in motor neurons of spinal cords of patients with amyotrophic lateral sclerosis BJMBR
Mendonça,D.M.F.; Chimelli,L.; Martinez,A.M.B..
Amyotrophic lateral sclerosis (ALS), a neurodegenerative disease of unknown etiology, affects motor neurons leading to atrophy of skeletal muscles, paralysis and death. There is evidence for the accumulation of neurofilaments (NF) in motor neurons of the spinal cord in ALS cases. NF are major structural elements of the neuronal cytoskeleton. They play an important role in cell architecture and differentiation and in the determination and maintenance of fiber caliber. They are composed of three different polypeptides: light (NF-L), medium (NF-M) and heavy (NF-H) subunits. In the present study, we performed a morphological and quantitative immunohistochemical analysis to evaluate the accumulation of NF and the presence of each subunit in control and ALS...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Amyotrophic lateral sclerosis; Spheroids; Neurofilament proteins; Immunohistochemistry.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000600015
Registros recuperados: 3
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