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Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug BJMBR
Zuardi,A.W.; Crippa,J.A.S.; Hallak,J.E.C.; Moreira,F.A.; Guimarães,F.S..
A high dose of delta9-tetrahydrocannabinol, the main Cannabis sativa (cannabis) component, induces anxiety and psychotic-like symptoms in healthy volunteers. These effects of delta9-tetrahydrocannabinol are significantly reduced by cannabidiol (CBD), a cannabis constituent which is devoid of the typical effects of the plant. This observation led us to suspect that CBD could have anxiolytic and/or antipsychotic actions. Studies in animal models and in healthy volunteers clearly suggest an anxiolytic-like effect of CBD. The antipsychotic-like properties of CBD have been investigated in animal models using behavioral and neurochemical techniques which suggested that CBD has a pharmacological profile similar to that of atypical antipsychotic drugs. The results...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cannabidiol; D9-Tetrahydrocannabinol; Cannabinoid; Anxiety; Antipsychotic; Schizophrenia.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000400001
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Diagnostic profile of inpatients as a determinant of length of stay in a general hospital psychiatric unit BJMBR
Hallak,J.E.C.; Crippa,J.A.S.; Vansan,G.; Zuardi,A.W..
The aim of this study was to determine if the diagnostic profile of inpatients of a psychiatric unit in a general hospital influences the length of stay. The results of a retrospective survey comprising the first 16 years of operation of the Psychiatric Unit of the Ribeirão Preto General Hospital (PURP) showed that the progressive increase observed in the length of stay correlated with the increase in percentage of schizophrenia diagnosis, after the 8th year of hospital operation, and of affective disorders, after the 12th year. The length of hospitalization kept increasing until the 16th year, even though there was no change in the diagnostic profile of the patients admitted to the unit. In a prospective study encompassing the next six months, 61...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Psychiatric unit; General hospital; Diagnostic category; Length of stay.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000900014
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Factor structure of Bech's version of the Brief Psychiatric Rating Scale in Brazilian patients BJMBR
Crippa,J.A.S.; Sanches,R.F.; Hallak,J.E.C.; Loureiro,S.R.; Zuardi,A.W..
The objective of the present study was to evaluate the factor structure of Bech's version of the Brief Psychiatric Rating Scale (BPRS), translated into Portuguese. The BPRS was administered to a heterogeneous group of psychiatric inpatients (N = 98) and outpatients (N = 62) in a University Hospital. Each patient was evaluated from one to eight times. The interval between consecutive interviews was one week for the inpatients and one month for the outpatients. The results were submitted to factorial analysis. The internal consistency of the total scale and of each factor was also estimated. Factorial analysis followed by normalized orthogonal rotation (Varimax) yielded four factors: Withdrawal-Retardation, Thinking Disorder, Anxious-Depression and...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Brief Psychiatric Rating Scale; Psychiatric status rating scales; Psychometrics; Portuguese version; Factorial analysis.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000014
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Glutamate-N-methyl-D-aspartate receptor modulation and minocycline for the treatment of patients with schizophrenia: an update BJMBR
Chaves,C.; Marque,C.R.; Trzesniak,C.; Machado de Sousa,J.P.; Zuardi,A.W.; Crippa,J.A.S.; Dursun,S.M.; Hallak,J.E..
Growing consistent evidence indicates that hypofunction of N-methyl-D-aspartate (NMDA) transmission plays a pivotal role in the neuropathophysiology of schizophrenia. Hence, drugs which modulate NMDA neurotransmission are promising approaches to the treatment of schizophrenia. The aim of this article is to review clinical trials with novel compounds acting on the NMDA receptor (NMDA-R). This review also includes a discussion and translation of neuroscience into schizophrenia therapeutics. Although the precise mechanism of action of minocycline in the brain remains unclear, there is evidence that it blocks the neurotoxicity of NMDA antagonists and may exert a differential effect on NMDA signaling pathways. We, therefore, hypothesize that the effects of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Schizophrenia; NMDA agonist; Glycine; Glutamate; Clinical trial; Minocycline.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001100002
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Proton magnetic resonance spectroscopy of the frontal, cingulate and perirolandic cortices and its relationship to skin conductance in patients with schizophrenia BJMBR
Sanches,R.F.; Crippa,J.A.S.; Hallak,J.E.C.; de Sousa,J.P.M.; Araújo,D.; Santos,A.C.; Zuardi,A.W..
The aim of the present study was to determine whether specific subgroups of schizophrenic patients, grouped according to electrodermal characteristics, show differences in the N-acetylaspartate/creatine plus choline (NAA / (Cr + Cho)) ratios in the frontal, cingulate and perirolandic cortices. Skin conductance levels (SCL) and skin conductance responses to auditory stimulation were measured in 38 patients with schizophrenia and in the same number of matched healthy volunteers (control). All subjects were submitted to multivoxel proton magnetic resonance spectroscopic imaging. When compared to the control group, patients presented significantly lower NAA / (Cr + Cho) ratios in the right dorsolateral prefrontal cortex (schizophrenia = 0.95 ± 0.03; control =...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Magnetic resonance spectroscopy; Skin conductance; Schizophrenia; N-acetylaspartate; Cingulate region; Dorsolateral prefrontal cortex.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001200015
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Reliability and validity of a Portuguese version of the Young Mania Rating Scale BJMBR
Vilela,J.A.A.; Crippa,J.A.S.; Del-Ben,C.M.; Loureiro,S.R..
The reliability and validity of a Portuguese version of the Young Mania Rating Scale were evaluated. The original scale was translated into and adapted to Portuguese by the authors. Definitions of clinical manifestations, a semi-structured anchored interview and more explicit rating criteria were added to the scale. Fifty-five adult subjects, aged 18 to 60 years, with a diagnosis of Current Manic Episode according to DSM-III-R criteria were assessed using the Young Mania Rating Scale as well as the Brief Psychiatric Rating Scale in two sessions held at intervals from 7 to 10 days. Good reliability ratings were obtained, with intra-class correlation coefficient of 0.97 for total scores, and levels of agreement above 0.80 (P < 0.001) for all individual...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mania; Rating scales; Reliability; Validity; Brief Psychiatric Rating Scale.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900019
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The response of social anxiety disorder patients to threat scenarios differs from that of healthy controls BJMBR
Mesquita,S.C.V.; Shuhama,R.; Osório,F.L.; Crippa,J.A.S.; Loureiro,S.R.; Landeira-Fernandez,J.; Graeff,F.G.; Del-Ben,C.M..
The objective of the present study was to evaluate the response of social anxiety disorder (SAD) patients to threat scenarios. First-choice responses to 12 scenarios describing conspecific threatening situations and mean scores of defensive direction and defensive intensity dimensions were compared between 87 SAD patients free of medication and 87 matched healthy controls (HC). A significant gender difference in the first-choice responses was identified for seven scenarios among HCs but only for two scenarios among SAD patients. A significantly higher proportion of SAD patients chose "freezing" in response to "Bush" and "Noise" scenarios, whereas the most frequent response by HCs to these scenarios was "check out". SAD males chose "run away" and "yell"...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Social anxiety disorder; Defensive response; Threat scenarios.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001200010
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The size and prevalence of the cavum septum pellucidum are normal in subjects with panic disorder BJMBR
Crippa,J.A.S.; Uchida,R.; Busatto,G.F.; Guimarães,F.S.; Del-Ben,C.M.; Zuardi,A.W.; Santos,A.C.; Araújo,D.; McGuire,P.K.; Graeff,F.G..
Panic disorder is thought to involve dysfunction in the septohippocampal system, and the presence of a cavum septum pellucidum might indicate the aberrant development of this system. We compared the prevalence and size of cavum septum pellucidum in 21 patients with panic disorder and in 21 healthy controls by magnetic resonance imaging. The length of the cavum septum pellucidum was measured by counting the number of consecutive 1-mm coronal slices in which it appeared. A cavum septum pellucidum of >6 mm in length was rated as large. There was no significant difference in the proportion of patients (16 of 21 or 76.2%) and controls (18 of 21 or 85.7%) with a cavum septum pellucidum (P = 0.35, Fisher's exact test, one-tailed), and no members of either...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Cavum septum pellucidum; Panic disorder; Neuroimaging; Magnetic resonance imaging.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000300013
Registros recuperados: 8
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