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Assembly of HE800 exopolysaccharide produced by a deep-sea hydrothermal bacterium into microgels for protein delivery applications ArchiMer
Zykwinska, Agata; Marquis, Melanie; Sinquin, Corinne; Cuenot, Stephane; Colliec-jouault, Sylvia.
Assembly of biopolymers into microgels is an elegant strategy for bioencapsulation with various potential biomedical applications. Such biocompatible and biodegradable microassemblies are developed not only to protect the encapsulated molecule but also to ensure its sustained local delivery. The present study describes the fabrication of microassemblies from a marine HE800 exopolysaccharide (EPS), which displays a glycosaminoglycan (GAG)-like structure and biological properties. HE800 EPS was assembled, through physical cross-linking with divalent ions, into microgel particles and microfibers using microfluidics. The microparticle morphology was highly affected by the polysaccharide concentration and its molecular weight. A model protein, namely Bovine...
Tipo: Text Palavras-chave: Marine exopolysaccharide; Microgel particles; Microfibers; Microfluidic; Microencapsulation; Protein release.
Ano: 2016 URL: https://archimer.ifremer.fr/doc/00311/42175/41475.pdf
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Microcarriers Based on Glycosaminoglycan-Like Marine Exopolysaccharide for TGF-β1 Long-Term Protection ArchiMer
Zykwinska, Agata; Marquis, Melanie; Godin, Mathilde; Marchand, Laetitia; Sinquin, Corinne; Garnier, Catherine; Jonchere, Camille; Chedeville, Claire; Le Visage, Catherine; Guicheux, Jerome; Colliec-jouault, Sylvia; Cuenot, Stephane.
Articular cartilage is an avascular, non-innervated connective tissue with limited ability to regenerate. Articular degenerative processes arising from trauma, inflammation or due to aging are thus irreversible and may induce the loss of the joint function. To repair cartilaginous defects, tissue engineering approaches are under intense development. Association of cells and signalling proteins, such as growth factors, with biocompatible hydrogel matrix may lead to the regeneration of the healthy tissue. One current strategy to enhance both growth factor bioactivity and bioavailability is based on the delivery of these signalling proteins in microcarriers. In this context, the aim of the present study was to develop microcarriers by encapsulating...
Tipo: Text Palavras-chave: Exopolysaccharide; Growth factor; Microparticles; Microfluidics; Bioactivity.
Ano: 2019 URL: https://archimer.ifremer.fr/doc/00477/58882/61432.pdf
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Microfluidic Encapsulation of Pickering Oil Microdroplets into Alginate Microgels for Lipophilic Compound Delivery ArchiMer
Marquis, Melanie; Alix, Valentin; Capron, Isabelle; Cuenot, Stephane; Zykwinska, Agata.
Alginate microgels are widely used as delivery systems in food, cosmetics, and pharmaceutical industries for encapsulation and sustained release of hydrophilic compounds and cells. However, the encapsulation of lipophilic molecules inside these microgels remains a great challenge because of the complex oil-core matrix required. The present study describes an original two-step approach allowing the easy encapsulation of several oil microdroplets within alginate microgels. In the first step, stable oil microdroplets were formed by preparing an oil-in-water (O/W) Pickering emulsion. To stabilize this emulsion, we used two solid particles, namely the cotton cellulose nanocrystals (CNC) and calcium carbonate (CaCO3). It was observed that the surface of the oil...
Tipo: Text Palavras-chave: Microparticles; Inonotropic gelation; Calcium carbonate particles; Cellulose nanocrystals; Microfluidics.
Ano: 2016 URL: https://archimer.ifremer.fr/doc/00333/44404/44272.pdf
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