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| Mataloun,M.M.G.B.; Leone,C.R.; Mascaretti,R.S.; Dohlnikoff,M.; Rebello,C.M.. |
| Several factors are associated with bronchopulmonary dysplasia. Among them, hyperoxia and lung immaturity are considered to be fundamental; however, the effect of malnutrition is unknown. Our objective was to evaluate the effects of 7 days of postnatal malnutrition and hyperoxia on lung weight, volume, water content, and pulmonary morphometry of premature rabbits. After c-section, 28-day-old New Zealand white rabbits were randomized into four groups: control diet and room air (CA, N = 17), control diet and ≥95% O2 (CH, N = 17), malnutrition and room air (MA, N = 18), and malnutrition and ≥95% O2 (MH, N = 18). Malnutrition was defined as a 30% reduction of all the nutrients provided in the control diet. Treatments were maintained for 7 days, after which... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Postnatal malnutrition; Hyperoxia; Lung development; Rabbit. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000700004 |
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| Cendon,S.P.; Battlehner,C.; Lorenzi-Filho,G.; Dohlnikoff,M.; Pereira,P.M.; Conceição,G.M.S.; Beppu,O.S.; Saldiva,P.H.N.. |
| We describe a short time model for inducing experimental emphysema in rats by chronic tobacco smoke inhalation. Three groups of male Wistar rats (6 months old) were studied: controls (N = 8), rats intoxicated for 45 days (s-45, N = 7) or for 90 days (s-90, N = 8). The exposed animals were intoxicated 3 times a day (10 cigarettes per exposure period), 5 days a week. Pulmonary damage was assessed by means of functional tests and quantitative pathological examination of the airways and lung parenchyma. The s-45 and s-90 animals were similar in terms of functional residual capacity (FRC) corrected for body weight (FRC/kg) but both groups of smoking rats exhibited significantly higher FRC/kg values than the controls (s-45 = 6.33; s-90 = 6.46; controls = 3.78;... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Passive smoking; Emphysema; Rats; Pulmonary function; Morphological analysis; Quantification. |
| Ano: 1997 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000017 |
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